摘要
经化学修饰的组织抗原,与正常组织成分有交叉反应的外来抗原、隔绝的体内自身成分及低分化的组织抗原等在一定条件下可刺激机体组织产生自身抗体.某些自身抗体因对系统性红斑狼疮（SLE）的判断具有高度特异性,已成为诊断SLE的血清指标或特异性抗体,有些自身抗体与疾病的活动性有相关性.因此,测定自身抗体有助于SLE的诊断,并对疾病的活动程度,观察治疗效果,指导临床用药具有重要的临床意义.
It is well known that chemical modified tissue antigens, foreign antigens with cross reactions to normal tissues, isolated components of the body, and poorly differentiated tissue antigens can induce the prodnhian of anto-antibodies in certain conditions. Some auto-antibodies, due to their high specificity, have been used to diagnose systemic lupus erythematosus. Besides, there is a correlation between some auto-antibodies and the active period of disease. Therefore, auto-antibody detection is helpful to diagnose systemic lupus erythematosus, to monitor disease activity or treatment effect, and to instruct clinical medication.
出处
《国际免疫学杂志》
CAS
2014年第5期419-423,共5页
International Journal of Immunology
关键词
系统性红斑狼疮
自身抗体
Systemic lupus erythematosus
Auto-antibodies
