摘要
目的分析抗人胸腺球蛋白（ATG）和环孢素A（CsA）结合临床护理治疗重型再生障碍性贫血（SAA）患者的疗效及不良反应,为SAA 的治疗提供参考.方法：选择2011 年1 月至2013 年12 月于我院接受ATG 联合CsA 治疗的SAA 患者12 例,在治疗的同时通过综合的护理,观察治疗后患者外周血象的变化、临床疗效和不良反应的发生率等情况.结果：治疗6 个月后,患者外周血象有进一步改善,血红蛋白恢复较好,中性粒细胞及血小板数有一定升高;用药后常见的不良反应为多毛症、牙龈肿胀和肝肾功能损害;经过ATG 和CsA 联合治疗,并悉心护理后,总有效率达到88.6%.结论：ATG、CsA 联合临床护理及心理干预对SAA 患者获得有效治疗具有重要作用.
ObjectiveTo investigate the effect and side effects of anti-thymocyte globulin（ATG） -cyclosporin A（CsA） therapy combined with clinical nursing of patients withsevere aplastic anemia（SAA） and provide basis for the treatment of SAA. Methods From Jan 2011 to Dec 2013, 12 SAA patients treated by ATG combined with CsA therapy in ourhospital were selected. Besides the treatment, comprehensive nursing were be used to the patients and the clinical effectiveness, the changes of peripheral blood cell counts and theincidence of different side effects in treatment period were observed. Results After 6 month treatment, their blood cells and hemoglobin recovery better, neutrophils and platelets havesome exaltation; the most common side effect was hirsutism, gingival swelling, and liver and kidney dysfunction; the total efficiency up to 88.6%. Conclusion Anti-thymocyteglobulin（ATG） -cyclosporin A（CsA） therapy combined with clinical nursing has an important role to patients with SAA to get effective treatment.
出处
《中医学报》
CAS
2014年第B07期327-328,共2页
Acta Chinese Medicine
