摘要
为了理解胶束向细胞输送药物过程中两者的相互作用机制,特别是两者融合的过程,使用分子动力学(MD)方法研究了双亲性两嵌段共聚物膜与共聚物胶束的相互作用机制.发现胶束与共聚物膜之间的距离、组成胶束的聚合物的数目等因素会强烈影响两者的融合.对于不同大小的胶束,其与共聚物膜融合的可能性会随着初始间距的变化而呈现出复杂的变化.结果表明:胶束的大小可以对其药物输运的效率产生影响.
In order to investigate the interaction mechanism between an amphiphilic copolymer bilayer membrane and micelle, including the fusion between them, molecular dynamics （MD） is used to simulate the interaction be- tween amphiphilic copolymer bilayer membrane and copolymer mieelle. It is found that the fusion between the mi- celle and the membrane is influenced by the distance between them as well as the amount of copolymer molecules composing the mieelle. It is indicated by our simulations that the size of the micelle could be an effective way to control the efficiency of drug delivery of mieelle to cells.
出处
《云南民族大学学报（自然科学版）》
CAS
2014年第5期326-330,共5页
Journal of Yunnan Minzu University:Natural Sciences Edition
基金
国家自然科学基金(11104192)
教育部科学技术研究重点项目(210208)
云南省应用基础研究计划(2010CD091)
关键词
双亲性嵌段共聚物膜
胶束
融合
amphiphilic copolymer bilayer membrane
micelle
fusion
