摘要
目的分析罗氟司特对COPD的临床疗效和安全性。方法选取2011年5月-2013年5月间的COPD患者76例，按照患者接受治疗的意愿随机分为对照组和实验组2组。给予对照组患者常规临床治疗，而实验组患者于常规治疗基础上采取罗氟司特药物治疗，对2种治疗方式的临床疗效情况和安全性进行比较分析。结果实验组中COPD患者的临床疾病治疗总有效率97．37％明显高于对照组84．21％，P〈O．05。实验组各肺功能和血气指标明显优于治疗前（P〈0．05），而对照组则无明显改善。实验组在治疗后SGRQ评分呼吸症状、活动受限、疾病影响各部分积分和总积分均出现明显下降（P〈O．05），但对照组变化不明显。从安全性来看，两组均无严重不良反应出现，实验组有1例出现腹泻，1例出现失眠；对照组有1例出现恶心，1例出现腹泻，2组对比差异无统计学意义（P〉0．05）。结论于常规临床治疗基础上给予COPD患者罗氟司特药物治疗能有效改善患者临床疗效，安全性高，值得临床积极推广使用。
Objective To analysis the clinical efficacy and safety of luo fluorine division for chronic obstructive pulmonary disease （COPD）. Methods In May 2011 to May 2013,76 patients with COPD, according to the wishes of patients treated were randomly divided into control group and experimental group two groups. Gave control group routine clinical treatment, and based on the conventional treatment group patients taking fluorine exeter, drug therapy, then obseved the clinical efficacy and safety of two kinds of treatments for comparative. Results The patients with COPD in the clinical disease treatment was significantly higher than the control group total effective rate 97.37%,84.21%, P 〈0.05. Group is obviously better than the lung function and blood gas index before treatment （ P 〈 0.05）, while the control group, no significant improvement. Experimental SGRQ scores after treatment of respiratory symptoms,limited activity,diseases affect each part integral and total integral are significantly decreased （P 〈0.05） ,but does not change significantly in the control group. From the point of safety, two groups had no serious adverse reactions occur, the experimental group has 1 ease appeared diarrhea, 1 case of insomnia. Control group 1 case of nausea, 1 case appeared diarrhea, compared the two groups, there was no significant difference （ P 〈0.05）. Conclusions Based on the conventional clinical treatment for patients with COPD, fluorine forrest can drug therapy can effectively improve the clinical curative effect, high safety, worth clinical actively promote the use.
出处
《国际呼吸杂志》
2014年第17期1295-1297,共3页
International Journal of Respiration
关键词
慢性阻塞性肺疾病
罗氟司特
治疗效果
Chronic obstructive pulmonary disease
Roflumilast
Treatment effect
