摘要
目的评价凉血解毒汤治疗血热型寻常型银屑病的临床疗效和安全性。方法将30例血热型寻常型银屑病患者,给予口服凉血解毒汤（生槐花、紫草、赤芍、白茅根等）治疗6周,通过观察记录患者治疗前后受累体表面积（body surface area,BSA）和病情严重程度指数（psoriasis area and severity index,PASI）评分以及皮肤病生活质量指数（dermatology life quality index,DLQI）评分,进行疗效评定;通过检测治疗前后患者血尿常规,肝肾功、心电图进行安全性评估。结果治疗后BSA和PASI评分较治疗前均有不同程度下降,差异具有统计学意义（P〈0.05）,患者DLQI评分较治疗前降低,且差异具有统计学意义（P〈0.05）。治疗总有效率为93.3%,无明显的不良反应。结论凉血解毒汤治疗血热型寻常型银屑病具有较好疗效,且安全性良好。
Objective To evaluate the clinical effect and safety of cooling blood and removing toxin decoction （ Liangxue Jiedu Decoction ） in the treatment of psoriasis vulgaris of blood-heat type. Methods 30 cases of patients with psoriasis vul- garis of blood-heat type were enrolled from dermatological outpatients of China-Japan friendship hospital, the affected Body Surface Area （BSA） as well as Psoriasis Area and Severity Index （PASI） score and dermatology life quality index （DLQI） score were observed and recorded before and after a consective 6 weeks of Liangxue Jiedu Decoction therapy. Subsequently, the efficacy and safety was respectively assessed by BSA, PASI and DLQI score as well as by routine urine, blood examina- tions, electrocardiogrmn, and the tests for the liver and kidney functions before and after the treatment. Results BSA and PASI score as well as DLQI score were declined after treatment compared with before treatment, a statistically difference was found （ P 〈 0.05）. The total effective rate of Liangxue Jiedu Decoction treatment was 93.3 %, and no obvious adverse reac- tion was found. Conclusion Liangxue Jiedu Decoction is a safe and effective prescription in the treatment of psoriasis vulgaris of blood-heat type.
出处
《长春中医药大学学报》
2014年第4期710-712,共3页
Journal of Changchun University of Chinese Medicine
基金
国家自然科学基金面上项目（81171502）
关键词
寻常型银屑病
血热证
凉血解毒汤
psoriasis xadgaris
blood-heat type
Liangxue Jiedu Decoction
