摘要
[目的]探讨如何利用植物多糖制备药用硬壳胶囊。[方法]以超低黏度海藻酸钠(SA)、羧甲基纤维素钠(CMC)、聚乙二醇-400(PEG-400)等作为材料制作植物多糖型药用胶囊硬壳。分别选取海藻酸钠、CMC以及PEG-400进行单因素试验分析成膜性、确定材料的配比范围。[结果]单因素试验表明,SA为12%、CMC为2%、PEG-400∶SA为1.25%时制作的药用胶囊硬壳拉伸强度最大,根据这些数据设计17组试验进行响应面分析,结果表明当SA为12.14%、CMC为2.08%、PEG-400∶SA为1.25%时拉伸强度最大,最适合做胶囊壳。验证性试验表明,按此配方常温溶胶混合制作的胶囊壳强度符合设计要求。[结论]研究可为我国利用植物多糖生产制备胶囊壳提供参考依据。
[Objective] To study preparation of medicinal hard capsule by plant polysaccharide.[Method] The plant polysaccharide type medicinal capsule shell was made with the ultra low viscosity sodium alginate （SA）,sodium carboxymethyl cellulose （CMC） and polyethylene glycol-400 （PEG400）.The optimal proportion of sodium alginate,CMC and PEG-400 was determined by single factor experiment.[Result]The results of single factor experiment show that sodium alginate,sodium carboxymethyl cellulose and PEG-400 concentration is 12％,2％ and 1.25％ respectively.The optimal proportion of sodium alginate,sodium carboxymethyl cellulose and PEG-400 was determined by response surface analysis.The results show that tensile strength of the plant polysaccharide type medicinal capsule shell is the maximum when SA is 12.14％,CMC is 2.08％,PEG-400 ratio SA is 1.25％.The formula is most suitable for the capsule shell.Validation experiments were carried out according to the formula.The strength of capsule shell meets requirements.[Conclusion] The study can provide reference basis for preparation of medicinal hard capsule by plant polysaccharide.
出处
《安徽农业科学》
CAS
2014年第27期9540-9543,共4页
Journal of Anhui Agricultural Sciences
基金
连云港市科技攻关项目
江苏高校优势学科建设工程资助项目
关键词
海藻酸钠
羧甲基纤维素钠
药用空心胶囊
Sodium alginate
Sodium carboxymethyl cellulose
Hollow plant capsule
