摘要
目的采用meta分析的方法研究钆塞酸二钠增强MRI诊断小肝癌的效果。方法收集2000-2014年国内外公开发表的钆塞酸二钠增强MRI诊断小肝癌的对比研究,对符合条件的所有原始研究按meta分析的要求和诊断试验的质量标准进行质量评估。采用软件检验研究间异质性并对诊断准确度指标进行分析绘制综合受试者工作特性曲线。结果符合纳人标准的6篇文献,纳入研究病人数397人,病灶数共796个。钆塞酸二钠汇总的敏感性分别为:0.91(95%CI,0.79-0.93);总的特异性分别为0.96(95%CI,0.94-0.98)。阳性似然比为19.56(10.07-38.00),阴性似然比为0.08(0.04-0.16)。SROC曲线下面积为0.9859。结论钆塞酸二钠增强MRI诊断小肝癌具有较高的诊断效能,可作为常规造影剂增强MRI无法筛查出的小肝癌的首选辅助方法。
Objective The purpose of the study was to perform a meta-analysis of all included studies of the diagnostic performance of Gd-EOB-DTPA enhanced Magnetic Resonance Imaging in the detection of small hepatocellular carcinoma （sHCC）.Methods Databases including MEDLINE, EMBASE were searched for relevant original articles published from January 2000 to April 2014. The methodological quality was assessed by using the quality assessment of diagnostic studies instruments.Results 6 studies were included in the meta-analysis with a total of 796 lesions. We detected heterogeneity between studies and evidence of publication bias. The methodological quality was moderate. The pooled weighted sensitivity with a corresponding 95% confidence interval （CI） was 0.91（95%CI, 0.79-0.93）, the specificity was 0.96（95%CI, 0.94-0.98）, the positive likelihood ratio was 19.56 （10.07-38.00）, the negative likelihood ratio was 0.08 （0.04-0.16）. The area under the receiver operator characteristic curve was 0.9859. Conclusion Enhanced MR imaging with Gd-EOB-DTPA is a reliable with a high sensitivity and specificity for detection of small hepatocellular carcinoma.
出处
《中国CT和MRI杂志》
2014年第6期54-57,67,共5页
Chinese Journal of CT and MRI
基金
广西医疗卫生适宜技术研究与开发项目(编号:S201301-08)
关键词
钆塞酸二钠
核磁共振
小肝癌
Gd-EOB-DTPA
Magnetic Resonance Imaging
Small Hepatic Cell Carcinoma
