摘要
目的探讨卡维地洛治疗心肌梗死后左心功能不全的临床效果。方法选取我院2011年6月至2012年5月收治的78例心肌梗死后左心功能不全患者,将其随机分为观察组和对照组,每组各39例,对照组采用常规治疗,观察组在对照组基础上加用卡维地洛治疗。比较两组患者治疗总有效率,治疗前后超声心动图左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)、左室射血分数(LVEF)数值。结果 1观察组治疗总有效率为97.4%(38/39),对照组为79.5%(31/39),两组比较差异具有统计学意义(P<0.05)。2治疗前两组超声心动图LVEDD、LVESD、LVEF比较,差异无统计学意义(P>0.05);治疗后,观察组超声心动图LVEDD、LVESD显著低于治疗前、LVEF显著高于治疗前,差异有统计学意义(P<0.01);治疗后组间比较,观察组LVEDD、LVESD显著低于对照组(P<0.05),LVEF显著高于对照组(P<0.01)。结论卡维地洛治疗心肌梗死后左心功能不全可有效改善左心功能,降低死亡率,值得推广。
Objective To investigate the clinical effect of therapy with carvedilol for left cardiac insufficiency after myocardial infarction. Methods 78 patients with left cardiac insufficiency after myocardial infarction in our hospital from June 2011 to May 2012 were selected and randomly divided into two groups, with 39 cases in each group. Patients in the control group received routine therapy, while patients in the observation group were treated with carvedilol on the basis of routine therapy. The total effective rate of therapy, the value of left ventricular end diastolic diameter （LVEDD）, left ventricular end systolic diameter （LVESD）, left ventricular ejection fraction （LVEF）of echocardiography before and after therapy were compared between the two groups. Results ①The total effective rate of the observation group was 97.4% （38/39）, higher than 79.5% （31/39） of the control group, and the difference between the two groups were statistically significant （P 〈0.05）. ②Before therapy, LVEDD, LVESD, and LVEF had no statistical difference between the two groups （P〉0.05）. After therapy, LVEDD and LVESD decreased significantly, and LVEF increased significantly in the observation group, with statistically significant difference （P 〈0.01）. After therapy, LVEDD and LVESD of the observation group were significantly lower than those of the control group （P 〈0.05）, and LVEF was significantly higher than that of the control group （P 〈0.01）. Conclusions The therapy with carvedilol for left cardiac insufficiency after myocardial infarction has significant effect on effectively improving left ventricular function and reducing mortality, which is worthy of promotion.
出处
《临床医学工程》
2014年第9期1129-1130,共2页
Clinical Medicine & Engineering
关键词
卡维地洛
心肌梗死
左心功能不全
Carvedilol
Myocardial infarction
Left cardiac insufficiency
