期刊文献+

卒中亚型与重组组织型纤溶酶原激活剂治疗急性缺血性脑卒中预后的关系

下载PDF
导出
摘要 目的探讨卒中亚型与rt-PA治疗急性缺血性脑卒中预后的关系。方法以收集发病4.5h内给予rt-PA溶栓的急性缺血性脑卒中患者作为研究对象。采用改良的Rankin量表评价神经功能恢复状况,并根据Rankin量表评分分为预后良好组(mRS评分0~1分)及预后不良组(mRS评分2~6分)。记录溶栓后颅内出血、症状性颅内出血及90d时病死率。结果预后良好组(55例)与预后不良组(46例)相比,两组在卒中亚型方面差别无统计学意义(P=0.941)。Logistic多因素回归分析显示卒中亚型与溶栓预后无关(P=0.608,OR为0.605,95%CI为0.089~4.123),也与症状性颅内出血无关(P=0.267,OR为0.974,95%CI为0.929~1.020)。与大动脉粥样硬化型相比较,心源性栓塞型、小动脉闭塞型、其他型的卒中患者在90d内溶栓预后良好率差异无统计学意义(分别是P=0.987,P=0.763,P=0.578)。结论卒中亚型与急性缺血性脑卒中患者静脉溶栓预后无关。
出处 《福建医药杂志》 CAS 2014年第4期94-97,共4页 Fujian Medical Journal
  • 相关文献

参考文献10

  • 1The National Institute of Neurological Disorders and Stroke rt- PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke [J]. N Engl J Med, 1995, 333 (24), 15101-1587. 被引量:1
  • 2Haeke W, Kaste M, Bluhmki E, et al. Thrombolysis with al- teplase 3 to 4.5 hours after acute isehemie stroke [J]. N Engl J Med, 2008, 359 (13): 1317-1329. 被引量:1
  • 3Hacke W, Donnan G, Fieschi C, et al. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS. ECASS and NINDS rt-PA stroke trials [J]. Lancet, 2004, 363 (9411): 768-774. 被引量:1
  • 4Madden K P, Karanjia P N, Adams H P Jr, et al. Accuracy of initial stroke subtype diagnosis in the TOAST study. Trial of ORG 10172 in Acute Stroke Treatment [J]. Neurology, 1995, 45 (11): 1975-1979. 被引量:1
  • 5HUANG Yin-hui,ZHUO Shi-tu,CHEN Ya-fang,LI Ming-mei,LIN You-yu,YANG Mei-li,CHEN Zhen-jie,CAI Ruo-wei.Factors influencing clinical outcomes of acute ischemic stroke treated with intravenous recombinant tissue plasminogen activator[J].Chinese Medical Journal,2013(24):4685-4690. 被引量:19
  • 6Molina C A, Montaner J, Arenillas J F, et al. Differential pat- tern of tissue plasminogen activator induced proximal middle cer- ebral artery recanalization among stroke subtypes [J]. Stroke, 2004, 35 (2): 486-490. 被引量:1
  • 7Adams H, Delzoppo G, Alberts M, et al. Guidelines for the early management of adults with ischemic stroke., a guideline from the American Heart Association/American Stroke Associa- tion Stroke Council, Clinical Cardiology Council, Cardiovascu- lar Radiology an d Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Re- search Interdisciplinary Working Groups: The American Acade- my of Neurology affirms the value of this guideline as an educa- tional tool for neurologists [ J ]. Stroke, 2007, 38 ( 5 ):1655-1711. 被引量:1
  • 8Yeo L L, Paliwal P, Teoh H L, et al. Early and continuous neurologic improvements after intravenous thrombolysis are strong predictors of favorable long term outcomes in acute ische- mic stroke [J]. J Stroke Cerebrovasc Dis, 2013, 22 (8): e590-596. 被引量:1
  • 9Frank B, Fulton R, Weimar C, et al. Impact of atrial fibrilla- tion on outcome in thrombolyzed patients with stroke: evidence from the Virtual International Stroke Trials Archive (VISTA) [J]. Stroke, 2012, 43 (7): 1872-1877. 被引量:1
  • 10Nikneshan D, Raptis R, Pongmoragot J, et al. Predicting Clinical Outcomes and Response to Thrombolysis in Acute Stroke Patients With Diabetes [J]. Diabetes Care, 2013, 36 (1): 2041-2047. 被引量:1

二级参考文献1

共引文献18

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部