摘要
目的 ：回顾性分析原发性肝细胞癌（hepatocellular carcinoma,HCC）直径和假包膜与经动脉化学栓塞（transarterial chemoembolization,TACE）疗效之间的关系,并分析二者与TACE术后甲胎蛋白（alpha-fetoprotein,AFP）下降程度及生存的关系。方法 ：收集172例HCC患者的临床病理资料。采用Ridit法分析肿瘤直径和假包膜与TACE术后肿瘤内碘油存积的关系,采用Spearman等级相关分析二者与TACE术后AFP下降的关系,采用Kaplan-Meier法计算累计生存率,log-rank检验不同肿瘤直径和假包膜之间生存时间的差异。结果 ：肿瘤直径〈5cm、5～10 cm及〉10 cm3组之间的碘油存积差异有统计学意义（F=49.215,P〈0.05）;假包膜完整组、不完整组及无假包膜组的碘油存积差异也有统计学意义（F=44.308,P〈0.05）。肿瘤直径与TACE术后AFP下降呈负相关（r=-0.357,P〈0.05）;假包膜完整程度与TACE术后AFP下降呈正相关（r=0.753,P〈0.05）。肿瘤直径〈5 cm、5～10 cm及〉10 cm这3组的中位生存期分别为22.9、17.4和7.2个月（P〈0.05）;假包膜完整组、不完整组及无假包膜组的中位生存期分别为24.6、18.2和10.6个月（P〈0.05）。结论 ：HCC肿瘤直径越小以及假包膜越完整,TACE术后碘油存积越好,术后AFP下降越显著,中位生存期越长,累计生存率也较高。
Objective： To retrospectively analyze the relationship between the diameter and pseudo- capsule of hepatocellular carcinoma （HCC） and the curative effect of transarterial chemoembolization （TACE）. Subsequently, the relationships of the diameter and pseudo-capsule of HCC with the descent of serum alpha-fetoprotein （AFP） level and survival time were analyzed. Methods： The clinical records of 172 patients with HCC were collected. The relationships of diameter and pseudo-capsule of tumor with lipiodol-filling in HCC tissues were analyzed by Ridit analysis. Meanwhile, the relationships of the diameter and pseudo-capsule of tumor with the descent of serum AFP level were analyzed by Spearman rank correlation. In addition, the cumulative survival rate was calculated by Kaplan-Meier method. Then, it was judged whether the survival time of the patients with HCC was significantly different according to the diameter and pseudo-capsule of tumor by log-rank analysis. Results： The amounts of lipiodol-filling in HCC tissues amon 10 cm, and different were both significant including of serum lower than AFP level o g different diameters of tumor including lower than 5 cm, 5-10 cm and more than types of pseudo-capsules including complete, incomplete and no pseudo-capsule, ly different （F = 49.21 5, P 〈 0.05; F = 44.308, P 〈 0.05）. The diameters of tumor 5 cm, 5-10 cm and more than 10 cm were negatively correlated with the descent f patients treated with TACE （r = -0.357, P 〈 0.05）. The complete pseudo-capsule of tumor was positively correlated with the descent of serum AFP levels of the patients treated with TACE （r = 0.753, P 〈 0.05）. The median survival time of the patients with different diameters of tumor including lower than 5 cm, S-10 cm and more than 10 cm were 22.9, 1 7.4 and 7.2 months, respectively （P 〈 0.05）. The median survival time of HCC with complete, incomplete and no pseudo-capsules were 24.6, 18.2 and 10.6 months, respectively （P 〈 0.05）. Conclusion： If the diamet
出处
《肿瘤》
CAS
CSCD
北大核心
2014年第8期734-738,共5页
Tumor
基金
卫生部医药卫生科技发展研究中心资助项目(编号:W2012FZ025)
关键词
原发性肝细胞癌
经动脉化学栓塞
肿瘤大小
假包膜
预后
Primary hepatocellular carcinoma
Transarterial chemoembolization
Tumor size
Pseudo-capsule
Prognosis
