摘要
目的：探讨结构脂肪乳及中/长链脂肪乳对危重症患者肝功能和血脂的影响。方法采用随机法将98例患者分为两组，即MCT/LCT组与STG组，两组均为49例，两组所患疾病、APACHE II评分、年龄及性别等均无显著性差异（P＞0.05），具有可比性。患者进入ICU后，立即对身体状况及病情进行评估，确定不存在肠外营养支持方面的禁忌证后采用MCT/LCT及STG进行治疗。在第1～2天静脉输注葡萄糖，第3天后开始实施肠外营养支持治疗，两组均连续治疗15d。结果采用两种不同的脂肪乳进行治疗后，两组的AST、TG及TCH、LDL-C差异有统计学意义（P＜0.05），MCT/LCT组的AST、TG、TCH及LDL-C值大于STG组。在HDL-C、DBIL、TBIL、ALP、及ALT方面，治疗前后两组的差异均不明显（P＞0.05）。结论在为危重症患者提供营养支持时，STG对血脂及肝功能各项指标的影响较小，应推广使用STG。
Objective To comparative analysis of the influence of structure fat emulsion and medium and long chain fat emulsion to liver function and blood lipid in patients with critical illness. Methods 98 ICU patients were randomLy divided into the MCT/LCT group and the STG group, 49 cases in each group. The disease, APACHE II score, age and gender of two groups were not significant difference （P 〉 0.05）. Two groups were comparable. After entering the ICU, the physical conditions of patients were immediately evaluated and determined that there were not parenteral nutritional support contraindications. The patients were treated with MCT/LCT or STG. The patients were given glucose infusion in the 1-2d, and treated with parenteral nutrition support therapy after 3d. Two groups were treated for 15d. Results After treatment with two different kinds of fat emulsion, there were significant differences between the two groups of AST, TG and TCH, LDL-C（P〈0.05）. AST, TG, TCH and LDL-C values of the MCT/LCT group were greater than those of STG group. In the HDL-C, DBIL, TBIL, ALP, and ALT of two groups, the differences between before treatment and after treatment were not significant （P〉0.05）. Conclusion To provide nutritional support for critically ill patients, STG has little effect on the indexes of blood lipid and liver function, should promote the use of STG.
出处
《中国医药科学》
2014年第15期198-200,216,共4页
China Medicine And Pharmacy
关键词
中
长链脂肪乳
结构脂肪乳
危重症
血脂
肝功能
Medium and long chain fat emulsion
Structure fat emulsion
Critical illness
Blood lipid
Liver function
