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慢性肾脏病骨代谢紊乱的相关分析 被引量:3

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摘要 目的了解慢性肾脏病(CKD)各期非透析患者矿物质及骨代谢紊乱(MBD)情况。方法比较本院176例CKD患者各期血钙、血磷、全段甲状旁腺激素(iPTH)、碱性磷酸酶(ALP)水平及其紊乱的发生率,并进行相关分析。结果 CKD5期血钙水平降低(P<0.001);血磷从CKD4期开始逐期升高(P<0.05);iPTH水平从CKD3期开始升高(P<0.05),并随疾病进展加重(均P<0.001)。176例患者中,低钙血症发生率为22.7%,高磷血症发生率为38.1%,高iPTH血症发生率为12.5%。多因素Logistic回归分析显示,低肾小球滤过率(GFR)、高iPTH是高磷血症的独立影响因素。结论 MBD在CKD早期即可出现,GFR<30mL·min-1·1.73m-2)后更加明显,低GFR、高iPTH是高磷血症的独立影响因素。
出处 《重庆医学》 CAS CSCD 北大核心 2014年第23期3073-3075,共3页 Chongqing medicine
基金 广西研究生教育创新计划资助项目(YCSZ2012036) 广西自然科学基金资助项目(2010GXNSFA013178) 广西卫生厅重点科研资助项目(重200845) 广西教育厅自筹经费科研课题(200911LX31)
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