摘要
目的 通过对I型糖尿病并发酮症 (DK)、酮症酸中毒 (DKA)的住院患儿进行血清 β 羟丁酸及其他生化指标的检测 ,确立血清 β 羟丁酸测定在该并发症临床诊断及疗效观察中的重要性及意义。 方法 对 4 4例I型糖尿病并发DK、DKA住院患儿采用全自动酶分析法测定血清 β 羟丁酸等项目。 结果 I型糖尿病并发DK及DKA患儿发病初血清β 羟丁酸 10 0 %增高。其中DK组测定值 0 .4 1～ 5 .6 9mmol/L ;中位数为 1.92mmol/L。DKA组测定值 0 .5 2～ 6 .5mmol/L ,中位数为 4 .12mmol/L ,两组间差异有显著意义。病人在接受胰岛素及其他相应治疗后血清 β 羟丁酸在 3～ 8d内迅速降到正常水平。 结论 血清 β 羟丁酸检测在I型糖尿病并发DK及DKA的临床诊断及疗效观察中显示出其特有的灵敏度和特异性 。
Objective To study the value of serum β hydroxybutyric acid determination in children with type I diabetes complicated with diabetes ketosis(DK) or diabetes keto acidosis(DKA). Methods Serum β hydroxybutyric acid was determined with automatic enzymatic assay techniques in 44 children patients(age 8 months～13 years) with type I diabetes complicated with DK or DKA. Results All children had elevated level of serum β hydroxybutyric acid. For DK group, the values were 0.41～5.69 mmol/L with median value of 1.92 mmol/L. For DKA group, serum β hydroxybutyric acid values were 0.52～6.5 mmol/L with median value of 4.12 mmol/L. There existed significant difference between the two groups. In the same patient, serum β hydroxybutyric acid would be decreased to normal level after effective treatment within three to eight days. Conclusion Serum β hydroxybutyric acid is a sensitive and spectific index in the diagnosis and treatment evaluation of type I diabetes complicated with DK or DKA.
出处
《上海医学检验杂志》
北大核心
2002年第4期219-220,共2页
Shanghai Journal of Medical Laboratory Sciences
