摘要
目的:探讨血府逐瘀汤对急性冠脉综合征患者血清血管性假血友病因子(vWF)和内皮素-1(ET-1)水平的影响及疗效观察。方法:85例急性冠脉综合征的患者随机分为观察组43例和对照组42例。两组患者均予以抗血小板、扩血管、调脂和改善心肌微循环等常规治疗。观察组在此基础上口服血府逐瘀汤200 ml,bid,连用4周。观察两组患者治疗前后血清vWF及ET-1水平的变化,并比较其临床疗效和不良反应发生率。结果:观察组患者治疗期间脱落3例,脱落率6.98%,对照组脱落2例,脱落率4.76%,两组脱落率比较差异无统计学意义(P>0.05)。治疗4周后,两组患者血清vWF和ET-1水平较前明显降低(P<0.05或0.01),观察组比对照组降低更明显(P<0.05);观察组临床总有效率为95.0%,明显高于对照组的80.0%(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:西医常规疗法加用中药血府逐瘀汤较单纯西医常规疗法可提高急性冠脉综合征的疗效,改善血管内皮细胞的功能,且未见明显的不良反应。
Objective： To discuss the curative effect of Xuefu Zhuyu decoctions （XZD） combined with the routine medical treat- ment in the patients with acute coronary syndrome （ACS） and the influence on serum yon Wilebrand factor （vWF） and endothelin-1 （ ET-I ） levels. Methods： Totally 85 cases of patients with ACS were divided into the observation group （ n = 43） and the control group （n = 42） randomly, and both were with medical treatment, such as anti-platelet, vasodilator, blood-lipid regulation, improvement of myocardial microcirculation and so on. The patients in the observation group were orally given 200ml XZD additionally, bid, for 4 weeks. The changes of serum vWF and ET-1 levels in the two groups before and after the medical treatment were observed, and the clinical curative effect and incidence of adverse reactions were compared as well. Results： Three and two cases of abscission were ap- peared in the observation group and the control group with abscission rate of 6.98% and 4.76%, respectively, and the difference was not statistically significant （ P 〉 0.05 ）. After the 4-week medical treatment, serum vWF and ET-1 leve｜s in the two groups were obvi- ously declined compared with those before the treatment （ P 〈 0.05 or 0.01 ）, and the declining rate in the observation group was much higher than that in the control group （P 〈 0.05 ）. The total clinical efficiency in the observation group was 95.0%, which was much higher than that in the control group （80.0%, P 〈 0.05 ）. The incidence of adverse reactions in the two groups showed no statistical difference （P 〉 0.05 ）. Conclusion： Compared with pure western routine medical treatment, western routine medical treatment com- bined with XZD, a traditional Chinese medicine, can enhance the curative effect of ACS and improve the function of vascular endotheli- al cell with no obvious adverse reaction.
出处
《中国药师》
CAS
2014年第8期1360-1362,共3页
China Pharmacist
