摘要
目的观察槐杞黄颗粒辅助治疗儿童原发性肾病综合征的疗效。方法选自本院肾内科病房2009年7月1日-2010年6月30日收住的病例共112例,其中男78例、女34例,发病年龄1.3～13.5岁,初次治疗的患儿且糖皮质激素治疗敏感。随机分为两组,在基本条件相似的条件下,对照组58例仅予激素治疗,治疗组54例加用槐杞黄颗粒。观察两组患儿蛋白转阴时间,复发及复发的次数,以及呼吸道感染的次数。同时在入院时及发病后6个月,分别测定部分患儿血清白细胞介素（IL）-2、4、6、10和肿瘤坏死因子（TNF）、γ干扰素（IFN-γ）。结果尿蛋白转阴治疗组在5～22 d,平均12.6 d;对照组在5～24 d,平均14.1 d。经1年时间的随访,治疗组复发9例,占16.67%;对照组复发20例,占34.48%,两组间存在显著性差异（P〈0.05）。治疗组38例反复呼吸道感染患儿中,32例呼吸道感染明显减少,减少幅度为84.21%;对照组40例反复呼吸道感染的患儿中,减少的有19例,减少幅度为47.50%,两组间存在显著性差异（P〈0.01）,复发患儿均与感染相关。血清IL-2水平发病时下降,复查后回升,治疗组比对照组恢复快,有显著性差异（P〈0.05）。IFN-γ发病时升高,复查时治疗组下降至正常,对照组降至正常水平以下,两者亦有显著性差异（P〈0.05）。其他指标IL-4、TNF发病时呈正常水平,复查均下降,两组间无差异。IL-6、10由于两组间发病时的水平即呈现差异,无明显意义。结论槐杞黄颗粒辅助治疗儿童肾病综合征可以减少近期的复发情况;从临床现象上推测与减少、预防呼吸道感染相关;槐杞黄颗粒可以影响机体细胞免疫功能。
Objective To investigate the efficacy of Huaiqihuang Granule in children with primary nephrotic syndrome. Methods There were 112 cases （78 male and 34 female, at the age of 1.3--13.5 years old） in the ward of Renal Department of Internal Medicine in Affiliated Children＇s Hospital, School of Medicine, Zhejiang University during July 1St, 2009 to June 30th, 2010, who were initially treated and sensitive to glucocorticoid. They were enrolled in the study randomly and were divided into two groups under the similar condition： group A （54 cases in treatment group with Huaiqihuang Granule） and group B （58 cases in control group with hormone instead of Huaiqihuang Granules）. We observed the duration of proteinuria turned into negative, the frequency of recurrence, the frequency of respiratory tract infection, and the changing of cytokines after the treatments. On the admission and six months after the onset of disease, the IL-2, -4, -6, and -10, TNF, and IFN-γ of some patient children were determined. Results The duration ofproteinuia being negative was 5--22 d （average 12.6 d） in the group A and 5--24 d （average 14.1 d） in the group B. After one year＇s follow-up, nine cases suffered recurrence in group A （16.67%）, while 20 cases in group B （34.48%）. There was statistically significant difference with P 〈 0.05. Among 38 cases who were suffered respiratory tract infection frequently in group A, the times of infection were significantly reduced in 32 cases, the reduction rate was 84.21%, while it was 47.50% in group B （P 〈 0.01）. All the recurrence patients were associated with infection. The level of IL-2 was low during disease, after recovery, it increased faster in group A than in group B （P 〈 0.05）. IFN-γ was elevated at the onset in both groups, after recovery it dropped down to normal in group A, and decreased under the normal level in group B. The TNF, IL-6, and -10 showed no significant deference between the two groups. Conclusion Huaiqihuang Granule can reduce the
出处
《中草药》
CAS
CSCD
北大核心
2014年第16期2375-2377,共3页
Chinese Traditional and Herbal Drugs
基金
浙江省中医药科学研究基金项目(2014ZA074)
浙江省科技厅公益技术研究社会发展项目(2012C33048)
关键词
槐杞黄颗粒
儿童
肾病综合征
糖皮质激素
复发
Huaiqihuang Granule, children
nephrotic syndrome
glucocorticoid
recurrence
