摘要
目的了解本院NICU病房血培养阳性的分布特点及对抗生素的耐药情况,便于为临床合理应用抗菌药物提供依据。方法对2011年7月-2013年7月重症监护病房的475例患儿进行血培养,对分离的菌株进行鉴定及药敏实验,按CLSI 2010版标准判读药敏试验结果。结果 475例患儿中共检出阳性菌株49株,血培养阳性率10.3%,革兰阳性菌占49%,其中凝固酶阴性的葡萄球菌(CNS)占阳性菌的54.2%;革兰阴性菌占51%,以肺炎克雷伯、大肠埃希菌为主分别占阴性菌的52%、24%。革兰阳性菌对万古霉素、利奈唑胺敏感。革兰阴性菌对阿米卡星、阿莫西林/克拉维酸、亚胺培南、左氧氟沙星敏感。结论应加强NICU血培养监测,以便临床医生及时了解血培养病原菌的耐药情况合理选用抗菌药物,减少耐药菌的产生。
Objective To investigate the distribution characteristics and antibiotic resistance of pathogens isolated from blood specimens of neonates in NICU,so as to provide basis for rational application of antibiotics In clinic. Methods From July2011 to July 2013,blood specimens were collected from 475 newborns in NICU for culture,then the pathogen strains were isolated for identification and drug sensitive test. The test results were analyzed according to standards of CLSI 2010. Results Forty-nine pathogen strains were isolated from 475 blood culture specimens（10. 3%）. Gram-positive cocci accounted for 49%,with coagulase-negative staphylococcus as predominant,accounting for 54. 2%; While Gram-negative bacteria accounted for51%,mainly Klebsiella pneumoniae（52%） and E coli（24%）. Gram-positive cocci were sensitive to vancomycin and linezolid. Gram-negative bacteria were sensitive to amikacim,amoxicillin/clavulainc acid,imipenem and levofloxacin. Conclusion Blood culture monitoring in NICU should be strengthened to provide timely information for clinicians to understand the antibiotic resistance of pathogens and select rational antibiotics,thus reducing the drug-resistant strains.
出处
《中国卫生检验杂志》
北大核心
2014年第15期2267-2268,2270,共3页
Chinese Journal of Health Laboratory Technology
关键词
新生儿
血培养
耐药性
Newborns
Blood culture
Drug resistance
