摘要
目的:探讨一种新结构的化学药头孢呋辛赖氨酸结晶化合物的成盐性。方法:采用红外化学成像技术和固体核磁共振技术,辅以粉末X-ray衍射分析和稳定性研究,证明样品以成盐形态存在。结果:头孢呋辛赖氨酸中无游离的L-赖氨酸存在;样品中头孢呋辛酸与L-赖氨酸的成盐位点应与头孢呋辛酸的4位羧基有关;样品具有专属的晶型和较好的化学稳定性。结论:本研究初步推定了样品为以头孢呋辛赖氨酸盐形态存在的化合物。
Objective：To explore the salification property of a chemical crystalline compound with new structure named cefuroxime lysine. Methods：That cefuroxime lysine sample was in salt form was proved by infrared chemical imaging technology and ^13C solid nuclear magnetic resonance technology associated with powder X-ray diffraction analysis and stability study. Results：It was shown that no free L-lysine was present in cefuroxime lysine crystalline compound and the site at which cefuroxime acid was conjugated with L-lysine was related to 4-carboxyl in cefuroxime acid,and the cefuroxime lysine sample was in specific crystal form with higher chemical stability. Conclusion ：The results of this research suggested that cefuroxime is linked with lysine by a chemical bond to form a salt.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2014年第16期1875-1880,1892,共7页
Chinese Journal of New Drugs
基金
国家"重大新药创制"科技重大专项(2011ZX09303-001)
关键词
头孢呋辛赖氨酸
红外化学成像
^13C固体核磁共振
成盐
cefuroxime lysine
infrared chemical imaging
^13 C solid nuclear magnetic resonance
salification
