摘要
目的：探讨重组人脑利钠肽治疗急性心肌梗死后心力衰竭的效果。方法选择2012年10月~2014年1月本院收治的急性心肌梗死后心力衰竭患者62例，将患者随机分为观察组和对照组，各31例。对照组给予常规抗心衰治疗：利尿剂、扩血管药物、硝酸甘油；观察组在对照组的基础上使用重组人脑利钠肽治疗。观察对比两组患者治疗前后的心率、血压，超声心动图等参数的变化以及治疗效果。结果观察组的总有效率为93.55%，显著高于对照组的77.42%（P〈0.05）；观察组治疗后的收缩压、舒张压以及心率分别为（108.1±13.8）mm Hg、（79.5±9.7）mm Hg、（83.7±11.4）/min，对照组分别为（120.6±17.1）mm Hg、（85.6±10.4）mm Hg、（93.5±19.1）/min，观察组治疗后血压、心率的改善情况优于对照组（P〈0.05）；观察组治疗后的LVEF、LVFS、PEV分别为（63±8.1）%、（34.1±3.8）%、（0.87±0.14）m/s，对照组分别为（54.1±9.4）%、（31.6±2.6）%、（0.65±0.23）m/s，治疗后的心功能改善情况明显优于对照组（P〈0.05）。结论重组人脑利钠肽治疗急性心肌梗死后心力衰竭的效果显著，能够明显改善患者的临床症状，值得临床推广应用。
Objective To discuss the effect of recombinant human brain natriuretic peptide （rhBNP） in the treatment of heart failure after acute myocardial infarction （AMI）. Methods 62 patients with heart failure after AMI treated in our hospital from October 2012 to January 2014 were selected and they were randomly divided into the two groups,there were 31 cases in each group.The control group was given the routine anti heart failure：diuretics,vasodilators and nitro-glycerin,the observation group was treated by rhBNP on the basis of the control group.Change of heart rate,blood pres-sure and parameters of echocardiography before and after treatment,the treatment effecct of the two groups were ob-served and compared. Results The total effective rate in the the obervation group （99.55%） was obviously higher than that in the control group （77.42%） （P〈0.05）;systolic pressure, diastolic pressure and heart rate after treatment in the ob-servation group was （108.1±13.8） mm Hg,（79.5±9.7） mm Hg,（83.7±11.4）/min respectively,while the control group was （120.6±17.1） mm Hg,（85.6±10.4） mm Hg,（93.5 ± 19.1）/min,improvement of blood pressure,heart rate after treatment in the observation group was better than that in the control group （P〈0.05）;LVEF,LVFS,PEV after treatment in the obser-vation group of was （63±8.1）%,（34.1±3.8）%,（0.87±0.14） m/s respectively,while the control group was （54.1±9.4）%,（31.6±2.6）%, （0.65±0.23） m/s respectively,cardiac function improvement after treatment in the observation group was signifi-cantly better than the control group （P〈0.05）. Conclusion The effect of rhBNP treating heart failure after AMI,and it can significantly improve the symptoms of patients,it is worthy of clinical promotion and application.
出处
《中国当代医药》
2014年第24期98-100,共3页
China Modern Medicine
关键词
重组人脑利钠肽
急性心肌梗死
心力衰竭
硝酸甘油
疗效
Recombinant human brain natriuretic peptide Acute myocardial infarction Heart failure Nitroglycerin Cu-rative effect
