摘要
目的：比较国产与进口紫杉醇注射液对肿瘤的治疗效果及安全性。方法选取2010年1月∽2014年1月本院收治的应用紫杉醇注射液化疗方案诊治的23例乳腺癌患者、14例子宫颈癌患者、10例肺癌患者和3例卵巢癌患者，将其随机分为国产紫杉醇组和进口紫杉醇组各25例，比较两组的临床疗效。结果国产紫杉醇组和进口紫杉醇组的有效率分别为64.0%和52.0%，差异无统计学意义（P〉0.05）。两组毒副作用差异无统计学意义（P〉0.05）。国产紫杉醇价格更低廉，为（45571.5±2479.6）元，进口紫杉醇的平均价格为（94863.8±3278.9）元，两组比较差异有统计学意义（P〈0.05）。结论国产与进口紫杉醇治疗乳腺癌、子宫颈癌、肺癌和卵巢癌的临床效果相当，但国产紫杉醇明显价格更低，为临床上合理用药指明了方向。
Objective To compare the therapeutic effect and safety of domestic and imported paclitaxel injections on treating tumors. Methods 50 cases of patients including 23 ones with breast cancer,14 cervical cancer,10 lung cancer, and 3 ovarian cancer were adopted chemotherapy regimens with paclitaxel injection from January 2010 to January 2014 were randomly selected from case management database in our hospital.They were evenly divided into two groups,do-mestic paclitaxel injection group and imported paclitaxel injection （taxol） group.The related data were collected and processed,and the dosage of paclitaxel injection,price of each course of treatment,effect,and toxic and side effect were retrospectively analyzed. Results The effective rate of domestic paclitaxel group was 64.0%,and was 52.0% in imported paclitaxel group,the difference was not significant （P〉0.05）.The side effective rate in domestic and imported paclitaxel injection group had no significant difference （P〉0.05）.The price of domestic paclitaxel was （45 571.5±2479.6） yuan, while the average price of imported paclitaxel was （94 863.8±3278.9） yuan,which displayed statistical difference （P〈0.05）. Conclusion There is no statistical difference in therapeutic effect on treating breast cancer,cervical cancer,lung cancer or ovarian cancer by domestic and imported paclitaxels.In comparison with imported paclitaxel,the price of do-mestic one is lower,which points out the direction for rational drug use in clinic.
出处
《中国当代医药》
2014年第22期84-86,共3页
China Modern Medicine
关键词
紫杉醇
抗肿瘤
毒副作用
Paclitaxel
Antitumor
Toxic and side effect
