摘要
以丁烯氟虫腈为囊芯化合物，带有相反电性的壳聚糖和海藻酸钠为囊壁材料，采用层层自组装技术制备了丁烯氟虫腈微胶囊，通过流点法筛选出十二烷基苯磺酸钠为丁烯氟虫腈的分散稳定剂。对制备的微胶囊进行了表征，系统研究了丁烯氟虫腈微胶囊的载药量、包封率、缓释性能和抗光解性能随着组装层数增加的变化规律。结果表明，组装层数为6～8层的丁烯氟虫腈微胶囊的包封率达到80％以上，达最高释放量所需要的时间为60h，光解率降到20％以下，综合效果最好。
Butylene fipronil-loaded microcapsules were prepared by layer-by-layer self-assembly of oppositely charged chitosan and sodium alginate as shell materials. Sodium dodecyl benzene sulfonate was selected as the dispersant by flowing point method. The prepared microcapsules were characterized. The effect of drug loadings, entrapment efficiency, release profiles and photo degradation rate with the increase of layers was systematically studied. The results show that microcapsules with six to eight layers are the best with the entrapment efficiency up to 80%, the release time of 60 h and the photolysis rate down to 20%.
出处
《应用化学》
CAS
CSCD
北大核心
2014年第9期1037-1043,共7页
Chinese Journal of Applied Chemistry
基金
山东省自然科学基金(ZR2009DM032)资助项目~~
关键词
丁烯氟虫腈
微胶囊
层层自组装
壳聚糖
海藻酸钠
microcapsules, layer-by-layer, butylene fipronil, chitosan, sodium alginate
