摘要
目的:探究甲基苯丙胺依赖者在戒断毒品的28周内心理状况的变化,以便更细致地了解甲基苯丙胺依赖者的戒断症状。方法:选取符合入组标准的甲基苯丙胺依赖者组成甲基苯丙胺依赖组(n=96),以末次吸食为基准点,分别在第2周、第8周、第16周和第28周应用症状自评量表(SCL-90)、汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)对其进行心理状况测试;同时,选取无药物滥用史的健康人群作为正常对照组(n=192),进行上述3个经典量表的测试。结果:在强制隔离戒毒期间,3个量表均提示,甲基苯丙胺依赖组分值在第2周最高,此后第8、16、28周分值均有下降趋势,其中第28周分值最低。但在汉密尔顿焦虑量表中,焦虑总分在第16周有小幅升高,且与第8周比较有统计学意义(P<0.05)。针对3个量表进行相关性分析,3者均呈正相关。结论:甲基苯丙胺依赖者戒断28周内存在严重的心理和情感问题,在戒断后第2周稽延性戒断症候群最为严重,其中焦虑、抑郁症候群最为显著。在第16周精神状况有小幅波动,此后各心理量表分值均呈现下降趋势。
Objective：In order to get a more detailed understanding of withdrawal symptoms of methamphetamine dependence, we explore changes in mental status within 28 weeks of drug withdrawal in methamphetamine dependence. Methods：The eligible methamphetamine addicts were enrolled into drug dependent group （ n = 96）, the Symptom Checklist 90 （ SCL - 90）, Hamilton Depression Scale （ HAMD ） and Hamilton Anxiety Scale （HAMA） were used for testing their mental status, respectively on 2 weeks, 8 weeks, 16 weeks and 28 weeks after last intake; meanwhile, healthy people with no history of drug abuse were taken as the normal control group （n = 192）, and received the same three classical scales tests. Resu./.ts.： During the period of compulsive withdrawal, three scales＇ results indicated that the score was highest in the first 2 weeks, then decreased in 8 weeks, 16 weeks, 28 weeks, and the score was lowest in the 28 weeks for methamphetamine dependent group. But in HAMA, the anxiety score were slightly increased in the 16 weeks, which was statistically higher than that in the 8 weeks（P 〈 0. 05 ）. For correlation analysis of these three scales, there was a positive correlation among them. Conclusion： Methamphetamine users had serious psychological and emotional problems within 28 weeks withdrawal of methamphetamine dependence. The protracted withdrawal syndromes, especially anxiety and depression, are the most serious in two weeks after withdrawal. Then the psychological scale scores showed a downward trend, except a slight fluctuation in the 16 weeks.
出处
《中国药物依赖性杂志》
CAS
CSCD
2014年第4期294-298,共5页
Chinese Journal of Drug Dependence
基金
公安部重点研究计划项目(2009ZDYJHT003)
国家科技支撑计划项目课题(2011BAK04B08)
关键词
甲基苯丙胺依赖
精神症状
心理
methamphetamine dependence
mental symptom
psychology
