摘要
目的 探讨窖蛋白-1（Caveolin-1）和RhoE在原发性肝癌（PLC）癌变过程中表达及其临床意义.方法 采用免疫组织化学法检测20例正常肝组织、32例肝硬化组织和68例PLC组织中Caveolin-1和RhoE表达水平.结果 Caveolin-1在正常肝组织、肝硬化组织和PLC组织中的表达率分别为85.00％ （17/20）、56.25％ （18/32）和27.94％（19/68）,两两比较差异有统计学意义（P＜0.05）,Caveolin-1表达水平与PLC癌细胞分化程度、血管浸润明显相关（P＜0.05）;RhoE蛋白在正常肝组织、肝硬化组织和PLC组织中的表达率分别为95.00％（19/20）、71.88％（23/32）和50.00％（34/68）,两两比较差异有统计学意义（P ＜0.01）;RhoE表达水平与PLC肿瘤大小、血管浸润、TNM分期明显相关（P＜0.05）.结论 Caveolin-1和RhoE在肝癌病变发展过程中起重要作用.
Objective To investigate the expression of Caveolin-1 and RhoE in primary liver carcinoma （PLC）,and their relation to the clinicopathological features and the prognostic value.Methods Immunohistochemical method was used to assess the expression of Caveolin-1 and RhoE in 20 normal liver tissues,32 cirrhosis tissues and 68 PLC tissues.Results The expression rate of Caveolin-1 in normal liver tissues,cirrhosis tissues and PLC tissues was 85.00％ （17/20）,56.25％ （18/32） and 27.94％ （19/68） with significant difference （P ＜ 0.05）.The expression levels of Caveolin-1 were related to histology grade and blood vessel invasion of PLC （P ＜ 0.05）.The expression rate of RhoE in normal liver tissues,cirrhosis tissues and PLC tissues was 95.00％ （19/20）,71.88％ （23/32） and 50.00％ （34/68） with significant difference （P ＜ 0.05）.There was a close relation between the expression of RhoE and histology grade,blood vessel invasion and TNM stage （P ＜ 0.05）.Conclusion The expression of Caveolin-1 and RhoE may play an important role in the carcinogenesis of liver carcinoma.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2014年第8期1805-1807,共3页
Chinese Journal of Experimental Surgery
