摘要
目的 评价12岁以下的反复呼吸道感染儿童补充脱氧核苷酸后的有效性及安全性。方法 采用前瞻性、多中心、随机开放性对照研究方法,入组反复呼吸道感染患者儿童72对,试验组采用脱氧核苷酸钠注射液[发作期10 mg/（kg？d）静脉滴注,同时给予抗感染药物,祛痰、镇咳药物],稳定期每周肌内注射或静脉滴注10毫克/（千克？周）,连续应用12个月,近期随访7~14 d评价疗效,远期则随访1年以上评价患儿预后情况及发生的不良事件。结果 近期研究结果显示,试验组急性症状持续时间（5.24±1.45）vs（7.21±1.73）,抗感染药物使用时间（4.57±1.28）vs（6.23±1.19）,住院时间（4.69±1.21）vs（6.43±1.35）,完全好转时间（7.14±1.28）vs（9.41±1.43）均短于对照组（P〈0.05）,可能与脱氧核苷酸提高CD3＋（58.9±9.8）vs（52.8±7.01）,CD4＋（47.9±6.7）vs（36.8±6.8）水平有关,另外试验组近期有效率痊愈率高于对照组（29.2%vs18.0%）。长期应用,脱氧核苷酸可减少平均急性发作次数（2.4±0.4）vs（4.9±2.1）。脱氧核苷酸不良反应为轻微发热,发生率22.2%。结论 对于反复呼吸道感染患儿,补充脱氧核苷酸急性期可显著缩短患儿病程,稳定期可减少反复发作次数。
Objective To evaluate the efficacy and safety of deoxyribonucleotide in intervention with repeated respiratory infection of children under 12. Methods A prospective, multicenter, randomized open-control study was conducted. 144 patients with repeated respiratory infection were included. The experiment group （n=72） were received conventional therapy and deoxyribonucleotide 10 mg/（kg.d） in acute period, and weekly 10 mg/kg for 12 months. The control group （n=72） were received conventional therapy only. Results Times of duration of symptoms（5.24±1.45）vs（7.21±1.73）, hospital time （4.69±1.21）vs（6.43±1.35）, antibiotic application time（4.57±1.28）vs（6.23±1.19） were shorter than the control group. And it may be related with that the deoxyribonucleotide improve the immune function. And the recovery rate of the experiment group was superior to the control group （29.2% vs 18.0%）. There is no obvious adverse effect in the course of treatment.Deoxyribonucleotide can decrease acute attack times （2.4±0.4）vs（4.9±2.1）, when long-time application. Conclusion For children with recurrent respiratory tract infection, acute phase complementary deoxynucleotide children can significantly shorten the course, stable can reduce recurrent episodes.
出处
《中国医药指南》
2014年第23期60-62,共3页
Guide of China Medicine
关键词
反复呼吸道感染
脱氧核苷酸
临床研究
Recurrent respiratory tract infections
Deoxynucleotides
Clinical research
