摘要
目的探析美托洛尔联合卡托普利治疗慢性肺源性心脏病的临床疗效。方法选择我院于2012年11月至2013年11月期间收治的40例慢性肺源性心脏病患者作为研究对象,随机分为观察组和对照组。两组患者首先均给予相应的常规治疗方法,具体包括确保充足的休息、合理氧疗、改善通气、控制感染、使用利尿剂和强心剂、纠正水和电解质平衡、并给予心肌能量药物等。观察组在此基础上联用美托洛尔和卡托普利进行治疗,比较两组患者的治疗有效率。结果观察组患者由于服用美托洛尔和卡托普利这两种药物,6例患者出现咳嗽症状,4例出现心动过缓,还有1例早期心衰加重,但是没有发生严重不良反应。在治疗有效率方面,观察组8例显效,9例有效,3例无效,总有效率为85.00%;对照组5例显效,8例有效,7例无效,总有效率为65.00%,两组之间的差异有显著统计学意义(P<0.05)。结论美托洛尔联合卡托普利治疗慢性肺源性心脏病具有较大的安全保障,两药的联合发挥协同作用强化了治疗效果,患者的生活质量得到提高,同时复发率也明显降低,应用效果显著。
Objective To investigate the clinical efficacy of metoprolol combined with captopril in the treatment of chronic pulmonary heart disease （CPHD）. Methods Forty CPHD patients admitted to our hospital from November 2012 to November 2013 were randomly divided into observation group and control group. Both groups received conventional treatment including ensuring adequate resting, appropriate oxygen therapy, improving ventilation, controlling infection, using diuretic and cardiotonic, correcting water and electrolyte imbalance, and administering drugs for increasing myocardial energy. In addition, the observation group received metoprolol and captopril. The response rate was compared between the two groups. Results In the observation group, 6 cases had cough, 4 cases had bradycardia, and one case had aggravated early heart failure; no severe adverse events occurred. In the observation group, $ cases showed marked response, 9 cases showed response, and 3 cases showed no response; the overall response rate was 85.00%. In the control group, 5 cases showed marked response, 8 cases showed response, and 7 cases showed no response; the overall response rate was 65.00%. There were significant differences in treatment responses between the two groups （P〈 0.05）. Conclusion Metoprolol combined with captopril has high safety in the treatment of CPHD. The combination therapy improves treatment outcome and patients＇ quality of life and significantly reduces recurrence rate.
出处
《心血管病防治知识（学术版）》
2014年第8期3-5,共3页
Prevention and Treatment of Cardiovascular Disease
