摘要
阿尔茨海默症(Alzheimer’s disease,AD)的病理学特征之一是患者脑内存在以β-淀粉样肽(Aβ)为主要成分的老年斑。大量的实验证据表明,以Aβ为靶目标,清除老年斑有助于提高患者的认知能力,是防治AD的一个重要研究方向。凝溶胶蛋白在细胞骨架结构重排和细胞运动等过程中都发挥重要作用。目前多个小组的研究成果显示,凝溶胶蛋白与AD的发生、发展密切相关。凝溶胶蛋白能够抑制Aβ积聚形成纤维,也能够引发已形成的Aβ纤维发生解聚。更重要的是,凝溶胶蛋白能够清除转基因AD模型小鼠脑内的老年斑和降低Aβ的水平。未来凝溶胶蛋白有可能被应用于AD的预防和治疗。
The presence of amyloid plaques is one of the neuropathological features of Alzheimer＇s disease （AD）. Amyloid plaques consist mainly of I）-amyloid peptide （Aβ）. Accumulating evidence shows, targeting AI3, clearance of amyloid plaques is helpful for improving recognition ability, and will be an important strategy for the treatment ofAD. Gelsolin plays an important role in the regulation of cell skeleton rearrangement and cell mobility. Results from several research groups show that gelsolin is closely related to the pathogenesis and development of AD. Gelsolin inhibits the aggregation of Aβ into fibrils, and also disaggregates the preformed Aβfibrils. More importantly, gelsolin reduces amyloid plaques and decreases the level of AI3 in transgenic mouse models of AD. In the future, gelsolin will be probably applied in the prevention and treatment of AD.
出处
《生命科学》
CSCD
2014年第8期829-834,共6页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(31200583)
高等学校博士学科点专项科研基金项目(20110091120045)
江苏省自然科学基金项目(BK2011569)
分子生物学国家重点实验室开放课题
