摘要
目的:分析196例糖皮质激素依赖性皮炎(简称激素依赖性皮炎)患者病因及1%吡美莫司乳膏的疗效。方法:采用问卷调查表的形式记录激素依赖性皮炎患者的临床资料,将符合入选条件的患者随机分为治疗组和对照组,治疗组给予1%吡美莫司乳膏外涂,每日2次,同时给予氯雷他定(开瑞坦)10 mg,每日1次口服;对照组仅给予开瑞坦10 mg,每日1次口服,观察其疗效和不良反应。结果:196例激素依赖性皮炎患者中,男女比为1:4.43,临床分型以面部中央型最为常见(52.55%),在外用的糖皮质激素中,以复方醋酸地塞米松乳膏(皮炎平)最多(39.29%)且多数为患者自行购买。治疗4周后,治疗组有效率(86.21%)高于对照组(25.00%),差异有统计学意义(X^2=5.388,P<0.01)。结论:激素依赖性皮炎主要是由于患者缺乏对糖皮质激素制剂正确使用的知识,导致滥用或误用外用糖皮质激素制剂所致。1%吡美莫司乳膏治疗激素依赖性皮炎安全有效。
Objective： To analyse the therapeutic effect of 1% pimecrolimus cream for the treatment of patients with corticosteroid-dependent dermatitis, Methods： Questionnaires were used to record clinical informations of the patients with corticosteroiddependent dermatitis, All patients consistent with the inclusion criteria of the study were randomly divided into treatment group and control group. The treatment group were given topical 1% pimeerolimus cream twice a day and 10mg clarityne once a day, meanwhile the control group were given 10mg clarityne once a day. The course of treatment was 4 weeks, The therapeutic effect and adverse reactions were evaluated after treatmenL Results： Among the 196 patients with corticosteroid--dependent dermatitis, the ratio of male to female was 14.43. The facial central type was the most common in the clinical classification （52.55%）. Compound dexamethasone acetate ointment was the most commonly used topical corticosteroid preparation（39.29%）, which was usually bought by the patients themselves. After treatment of 4 weeks, the effective rate of treatment group was higher than that of the control group （86.21%vs25%）, the difference was statistically significant（x2=5.388, P〈0.01）. Conclusion： Corticosteroid-dependent dermatitis is mainly caused by abuse or misuse of topical eorticosteroids, the fundamental reason is due to the insufficient knowledge of how to use corticosteroid preparation rightly. 1% pimecrolimus cream is safe and effective for the treatment of corticosteroid--dependent dermatitis.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2014年第8期500-501,共2页
Journal of Clinical Dermatology
