摘要
目的:探讨介入化疗在高危妊娠滋养细胞肿瘤治疗中的应用。方法:2008年7月至2012年7月,在我院进行介入化疗的高危GTN患者21例。末次妊娠的性质来源于葡萄胎者10例,流产后8例,中孕引产后1例,足月产后2例。21例高危GTN患者均采用EMA-EP介入化疗方案,VP16 100mg/m2+0.9%NS 40ml,d8介入;DDP 80mg/m2+0.9%NS 100ml,d8介入。介入化疗前后均行妇科检查、彩色多普勒超声检查、胸部X线或肺部CT检查、血β-HCG水平测定以明确诊断和进行疗效判定。结果:21例患者共行39次动脉插管,其中双侧子宫动脉插管24次,支气管动脉插管8次,左侧卵巢动脉插管2次,肠系膜下动脉插管2次,膀胱上动脉插管2次,阴部内动脉插管1次。介入化疗的有效率为95.2%。结论:介入化疗能提高高危GTN患者的化疗效果,降低化疗的耐药问题,有可能缩短治疗疗程,更重要的是可以保留脏器功能。对于高危GTN患者,介入化疗提供了新型、高效的方法。
To study the application of interventional chemotherapy in the high risk gestational tropho-blastic neoplasia. Methods:From 2008 July to 2012 July,there were 21 patients with high risk GTN with intervention-al chemotherapy in Shaanxi Province Tumor Hospital. The last pregnancy properties derived from 10 cases of hydatidi-form mole,8 cases of abortion,pregnancy induced labor in 1 case,2 cases of term pregnancy. 21 cases of high - risk GTN patients were treated with EMA - EP chemotherapy scheme. Determination of before and after interventional chemotherapy underwent gynecological examination,color Doppler ultrasonography,chest X ray or lung CT examina-tion,the blood β - HCG levels were determined to confirm the diagnosis and curative effect. Results:A total of 39 ar-tery intubation,the bilateral uterine artery catheterization of bronchial artery intubation 24 times,8 times,2 times the left ovarian artery,the inferior mesenteric artery intubation 2 times,2 times the bladder artery,internal pudendal artery 1 time. The effective rate was 95. 2% . Conclusion:Intervention chemotherapy can improve the effect of chemotherapy for patients with high risk GTN,reducing the drug resistance of chemotherapy,may shorten the course of treatment, more importantly can preserve organ function. For the high - risk patients with GTN,intervention chemotherapy may be a new efficient method.
出处
《现代肿瘤医学》
CAS
2014年第8期1931-1933,共3页
Journal of Modern Oncology
关键词
妊娠滋养细胞肿瘤
介入化疗
动脉栓塞
gestational trophoblastic neoplasia
interventional chemotherapy
arterial embolism