摘要
目的探讨妊娠高血压综合征(PIH)患者分娩前后血清胱抑素C(CysC)的变化及临床研究价值。方法选择92例PIH患者为观察组,其中轻度PIH 34例,中度PIH 31例,重度PIH 27例,同期60例正常孕妇为对照组,于妊娠晚期及产后7天分别监测各组孕妇CysC和血清肌酐(SCr)、尿素氮(BUN)、尿酸(UA)水平。结果妊娠晚期重度PIH患者血清CysC水平明显高于对照组和轻度PIH及中度PIH患者(P<0.05),且随PIH发生的严重程度不同差异越明显;重度PIH组SCr、UA、BUN值均高于对照组和轻度PIH组(P﹤0.05)。与妊娠晚期比较,产后7天各组CysC值均显著降低(P﹤0.01);BUN值:产后7天对照组、轻度PIH组、中度PIH组均高于妊娠晚期(P均≤0.01);SCr值:产后7天重度PIH组低于妊娠晚期(P<0.05);UA值:产后7天对照组高于妊娠晚期(P<0.05),重度PIH组低于妊娠晚期(P<0.01)。相关分析结果显示:孕妇血压与CysC及UA之间均具有密切相关性(P均<0.01)。结论血清CysC在PIH尤其是重度PIH时有明显变化,联合其他肾功能指标可以较灵敏地反映PIH患者的妊娠期肾功能损害和产后康复状况。
Aim To explore the changes and clinical value of cystatin C（ CysC） level in gravidas with pregnancy-induced hypertension syndrome（ PIH）. Methods 92 cases gravidas with PIH were selected as the observation group,including 34 cases of mild PIH,31 cases of moderate PIH and 27 cases of severe PIH. 60 cases of normal gravidas were used as control group. The CysC level and serum creatinine（ SCr）,blood urea nitrogen（ BUN）,uric acid（ UA） leve of all gravidas were detected in late pregnancy and postpartum 7 days. Results The cystatin C level in severe PIH gravidas was inscreased significantly compared with the healthy gravidas and mild PIH gravidas and moderate PIH gravidas in late pregnancy（ P〈0. 05）. And more severity of PIH more obvious differences. The SCr,UA and BUN level in severe PIH gravidas were significantly inscreased compared with the healthy gravidas and mild PIH gravidas in late pregnancy（ P〈0. 05）. The cystatin C level in all gravidas were decreased in postpartum 7 days compared with late pregnancy. The SCr,UA and BUN level were increased in the healthy gravidas and mild PIH gravidas,and the SCr,UA level were decreased in severe PIH gravidas in postpartum 7 days compared with late pregnancy. But the level of CysC and UA were significantly increased in severe PIH gravidas compared with the healthy gravidas and mild PIH gravidas in postpartum 7 days（ P〈0. 01）. Correlation analysis showed the blood pressure related to CysC and UA closely（ P〈0. 01）. Conclusion The CysC level in gravidas with PIH especially in gravidas with severe PIH have obvious change,which combined with other indicators of renal function can sensitively reflect the impairment of renal function and postpartum recovery in gravidas with PIH.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2014年第8期842-844,858,共4页
Chinese Journal of Arteriosclerosis
关键词
胱抑素C
妊娠高血压综合征
妊娠
产后
Cystatin C Pregnancy-Induced Hypertension Pregnancy Postpartum
