摘要
目的观察坎地沙坦联合比索洛尔治疗对老年高血压患者左心室肥厚及心功能不全的影响。方法将2011年7月-2012年8月收治的60岁以上的门诊或住院高血压患者117例随机分为对照组58例和试验组59例。对照组给予比索洛尔及苯磺酸左旋氨氯地平治疗,试验组给予坎地沙坦联合比索洛尔治疗。结果两组患者治疗3个月后的血压与治疗前比较均下降差异有统计学意义(P<0.05),两组患者治疗后的血压比较差异无统计学意义(P>0.05);两组患者治疗12个月后左心室舒张末期内径、室间隔舒张末期厚度、左心室后壁舒张末期厚度、心肌质量及左心室质量指数与治疗前后比较均下降,差异有统计学意义(P<0.05),射血分数与E/A升高,差异有统计学意义(P<0.05),且试验组结果优于对照组,差异有统计学意义。结论比索洛尔联合苯磺酸左旋氨氯地平或坎地沙坦均能有效控制老年高血压患者的血压及逆转左心室肥厚与心功能不全,但比索洛尔联合坎地沙坦的效果优于联合苯磺酸左旋氨氯地平。
Objective To evaluate the effects of combined bisoprolol and candesartan therapy on left ventricular hypertrophy and left heart function in in elderly patients with hypertension. Methods From July 2011 to August 2012, 117 elderly inpatients or outpatients with hypertension in our hospital were randomly divided into trial group and control group. Patients in the control group received levamlodipine besylate and bisoprolol, and patients in the trial group received candesartan and bisoprolol. Results There was no statistical difference between the two groups at baseline. Three months later, there was no obvious difference of the blood pressure levels between the two groups （P 〉 0.05）. The parameters of left ventricular hypertrophy and left heart function were improved at the end of follow-up in both the two groups, but the parameters of the trial group improved better than the control group （P 〈 0.05）. Conclusion In the elderly patients with hypertension, the combined bisoprolol and candesartan or levamlodipine besylate and bisoprolol therapy can improve left ventricular hypertrophy and left heart function, and the results are better for the combination of bisoprolol and candesartan.
出处
《华西医学》
CAS
2014年第7期1205-1207,共3页
West China Medical Journal
关键词
坎地沙坦
比索洛尔
老年高血压
左心室肥厚
心功能
Candesartan
Bisoprolol
Hypertension in the elderly
Left ventricular hypertrophy
Heart function
