摘要
目的探讨β-tubulinⅢ在胃癌组织中的表达,与肿瘤临床特征的关系及其对含紫杉烷类药物辅助化疗患者无病生存期(DFS)和总生存期(OS)的影响。方法收集34例胃癌根治术后应用含紫杉烷类药物辅助化疗且已经死亡患者的完整资料。应用免疫组织化学方法检测β-tubulinⅢ在术后病理组织中的表达,采用χ2检验分析β-tubulinⅢ表达与肿瘤临床特征的关系。采用Kaplan-Meier方法分析β-tubulinⅢ表达对含紫杉烷类药物辅助化疗患者生存期的影响。结果 (1)在34例胃癌患者中,β-tubulinⅢ表达15例,阳性表达率44.1%。β-tubulinⅢ的表达与肿瘤发病部位、大小、浸润深度、组织学类型、淋巴结转移、TNM分期无关。(2)β-tubulinⅢ阳性表达患者DFS 10个月,中位OS 18个月;β-tubulinⅢ阴性表达患者DFS 15个月,中位OS为21个月。β-tubulinⅢ阴性表达与阳性表达患者的DFS及中位OS相比,差异有显著性意义,P<0.05。结论β-tubulinⅢ在胃癌组织中的表达可能作为胃癌根治术后接受紫杉烷类药物敏感性的预测指标,但与肿瘤临床特征无关。
Objective To explore the correlation between the expression of β-tubulinⅢin gastric cancer tissues and clin-ical features of tumor, and to explore the effects of β-tubulinⅢon the disease free survival （DFS） and overall survival （ OS） of the patients treated with taxanes as adjuvant chemotherapy .Methods We have collected 34 patients who accepted radical resection of gastric cancer and taxanes as postoperative adjuvant chemotherapy .And all the 34 patients have died . The expression of β-tubulinⅢ was detected by immunohistochemical method .The correlation between the expression ofβ-tubulin Ⅲin gastric tissues and clinical features of tumor was analyzed by χ2 test.The correlation between the expres-sion of β-tubulin Ⅲon the survival of patients with taxanes as adjuvant chemot herapy was analyzed by Kaplan -Meier approach.Results In 34 cases of gastric cancer patients , 15 cases have β-tubulin Ⅲ expression,the positive expression rate is 44 .1%. The expression of β-tubulin Ⅲhas no correlation with tumor site ,size of tumor ,depth of invasion ,histo-logical type,lymphatic metastasis and TNM stage .The disease free survival （DFS） of patients with positive expression of β-tubulin Ⅲwas 10 months,and 18 months of overall survival（OS）.The disease free survival（DFS） of patients with nega-tive expression ofβ-tubulinⅢwas 15 months,and 21 months of overall survival（OS）.Compared positive expression of β-tubulin Ⅲpatients,the negatives have significant difference in DFS and median OS , P〈0.05.Conclusion The expres-sion of β-tubulinⅢin gastric tissues can be used as predictive indicators taxane drug sensitivity ,which after gastric cancer radical surgery , but does not correlate to the characteristics of clinical oncology .
出处
《大连医科大学学报》
CAS
2014年第3期225-228,261,共5页
Journal of Dalian Medical University
基金
大连市科委课题项目(2010ESF002)
