摘要
目的探讨乙型肝炎病毒(HBV)感染患者血清乙型肝炎五项标志物、乙型肝炎DNA(HBV-DNA)定量与乙型肝炎前S1抗原(PreS1Ag)联合检测的临床意义,以期能为临床诊断提供参考。方法 2012年1月-2013年7月对诊治的120例HBV感染患者空腹抽取静脉血检测乙型肝炎五项标志物、HBV-DNA定量与PreS1Ag,分析其结果,采用SPSS17.0软件进行统计分析。结果乙型肝炎五项标志物检测结果 HBsAg+HBsAb、HBsAg+HBeAg+HBcAb、HBsAg+HBeAb+HBcAb、HBsAg+HBeAg、HBsAg+HBeAb、HBsAg+HBcAb模式分别占2.50%、25.84%、45.00%、10.00%、5.83%、10.83%,PreS1Ag阳性率为60.83%,HBV-DNA阳性率为67.50%;HBV-DNA阳性患者中PreS1Ag阳性率74.04%高于HBeAg阳性率45.68%,差异有统计学意义(P<0.05)。结论乙型肝炎五项标志物、HBV-DNA、PreS1Ag联合检测更能准确判断HBV复制状况及传染性。
OBJECTIVE To investigate the clinical significance of joint detection of five hepatitis B markers, hepatitis B DNA （HBV-DNA） quantification and hepatitis B PreS1 antigen （PreS1Ag） in serum of patients with hepatitis B virus （HBV） infection so as to provide references for clinical diagnosis. METHODS For the 120 patients with HBV infection treated during Jan. 2012-Jul. 2013,peripheral venous blood samples were taken on an empty stomach for testing of five hepatitis B markers, HBV-DNA quantification and PreS1Ag. The results were analyzed byusing SPSS17.0 sotwer. RESULTS The testing results for the five hepatitis B markers indicated that HBsAg＋HBsAb, HBSAg＋ HBeAg＋ HBcAb, HBsAg＋ HBeAb＋ HBcAb, HBsAg＋ HBeAg, HBsAg＋HBeAb and HB- sAg＋HBcAb accounted for 2.50%, 25.84%, 45.00%, 10.00%, 5.83% and 10.00%, respectively. The posi- tive rate of preS1Ag was 60.83%, and the positive rate HBV-DNA was 67.50%. In patients with positive HBV- DNA, the positive rate of PreS1Ag was 74.04%, higher than 45.68% of the HBeAg, the difference was statistically significant （P〈0.05）. CONCLUSION The joint detection of the five hepatitis B markers, HBV-DNA, and PreS1Ag can diagnose the replication and infectivity of HBV more accurately.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第15期3890-3892,共3页
Chinese Journal of Nosocomiology
基金
河南科技厅重点基金资助项目(PY8906UYP)
