摘要
目的探讨脑出血患者住院期间发生肺部感染的病原菌分布及耐药性分析,以指导病情评估及临床抗菌药物应用。方法医院2008年2月-2013年2月收治的50例脑出血合并肺部感染患者,采集50例患者的痰标本进行病原菌培养及耐药性分析,采用WHONET5.3软件进行菌株鉴定及耐药性分析。结果 50份痰标本共培养出病原菌84株,其中革兰阴性菌52株、革兰阳性菌18株、真菌菌株14株;革兰阴性菌对头孢哌酮/舒巴坦的耐药率最低为13.46%;革兰阳性菌对利奈唑胺、万古霉素的耐药率最低分别为5.56%、11.11%;真菌对伏立康唑的耐药率最低为14.29%。结论住院脑出血患者由于意识障碍容易发生肺部感染,病原菌以革兰阴性菌为主,临床应根据病原菌培养结果及药敏试验选择合适敏感的抗菌药物。
OBJECTIVE To investigate ：the pathogen distribution of pulmonary infections and drug resistance in occurrence of cerebral hemorrhage patients during hospitalization. METHODS A total of 50 cases of cerebral hemorrhage patients with pulmonary infections were treated in our hospital from Feb. 2008 to Feb. 2013. The sputum specimens of 50 patients were collected and cultured for pathogens and analyzed for drug resistance. RESULTS A total of 84 strains were cultured out of 50 sputum samples, which consisted of 52 gram-negative strains （61.9 %）, including Pseudomonas aeruginosa , Acinetobacter baumannii , Klebsiella pneumoniae ; 18 gram-positive bacteria （21.4%）, mainly Staphylococcus aureus ; 14 fungal strains （16.70%）, mainly Candida albicans. Gram-negative bacteria had a sensitivity of ≥ 13.46% for cefoperazone/sulbaetam. Gram-positive bacteria had a sensitivity of 5.56% and 11. 11% for linezolid and vancomyein; fungi had a sensitivity of ≥ 14. 29% for vorieonazole. CONCLUSION Hospitalized patients with cerebral hemorrhage are prone to lung infections due to disturbance of consciousness, and pathogens are mainly gram-negative bacilli, clinicians should select the appropriate sensitive antibiotics according to culture and sensitivity test results.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第15期3677-3678,3681,共3页
Chinese Journal of Nosocomiology
基金
浙江省卫生厅重点基金资助项目(ZW-2010B-101231)
关键词
脑出血
肺部感染
病原菌
耐药性
Cerebral hemorrhage
Lung infection
Pathogens
Drug resistance
