摘要
目的探讨药物性肝损伤(DILI)的病因、临床特点、治疗及其疗效,提高临床医生对该病的认识。方法对本院74例DILI患者的病因、肝功能检查及治疗转归进行回顾性分析,以是否加用熊去氧胆酸(UDCA)分为熊去氧胆酸组和常规组,观察治疗2周的生物化学指标。结果引起肝损害的药物种类繁多,以中药为最多(59.46%),其次为抗感染药(18.92%)、抗结核药(8.11%),蒙药(4.05%),常规保肝治疗有效,熊去氧胆酸组疗效更加显著。结论 DILI与地区差异、药物种类密切相关,UDCA在治疗DILI方面疗效显著。
Objective To investigate the etiology, clinical features, treatment and its efifcacy of drug-induced liver injury in order to improve clinical doctors understanding of this problem. Methods Seventy four cases of hospital patients with drug-induced liver injury were divided into UDCA group and without UDCA group, whose etiology, liver function and treatment outcome were retrospectively analyzed and whose liver function were assessed two weeks after treatment. Results A wide variety of drugs can cause liver damage, the most were traditional Chinese medicine （59.46%）, followed by anti-inlfammatory drugs （18.92%）, and then were anti-TB drugs （8.11%） and Mongolian drug （4.05）. Conventional liver protecting treatment was effectively, and UDCA group showed better efficacy. Conclusions Drug-induced liver injury was closely related to regional differences and drug variety. The efifcacy of UDCA group in the treatment of drug-induced liver injury were signiifcant.
出处
《中国肝脏病杂志（电子版）》
CAS
2014年第2期35-37,共3页
Chinese Journal of Liver Diseases：Electronic Version
基金
内蒙古自治区科技厅计划项目(kjt12sf032)
关键词
药物性肝损伤
治疗
回顾性分析
Drug-induced liver injury
Treatment
Retrospectively analysis
