摘要
目的:系统评价《金匮要略》瓜蒌薤白类方治疗不稳定型心绞痛的临床疗效。方法:检索中国学术文献总库(CNKI)、万方数据库、中国生物医学文献数据库(CBM)、The Cochrane Library、PubMed等数据库,搜集瓜蒌薤白类方治疗不稳定型心绞痛的随机对照试验,按照Cochrane协作网推荐的方法评估纳入研究的偏倚风险,运用RevMan 5.2.6软件完成异质性检验、Meta-分析、敏感性分析、倒漏斗图分析等相关统计分析。结果:共纳入14项合格研究,均存在较高的方法学偏倚风险,Meta-分析显示瓜蒌薤白类方在改善心绞痛症状方面合并效应量RR=1.24,95%CI[1.18,1.31],改善心电图表现方面合并效应量RR=1.29,95%CI[1.19,1.39],结果均具有统计学意义;敏感性分析提示结果稳定;倒漏斗图分析显示不对称。结论:瓜蒌薤白类方可提高不稳定型心绞痛的临床疗效,但由于纳入研究的偏倚风险较高,尚需要开展样本量充足、设计合理、执行严格的临床试验进行验证。
Objective：To systematically assess the efficacy of the associated prescriptions of Gualou and Xiebai on unstable angina pectoris. Methods：Randomized controlled trials of associated prescriptions of Gualou and Xiebai on unstable angina pectoris were retrieved from the Cochrane library,PubMed,CNKI,Wanfang database and CBM. The risk of bias of included studies was assessed according to the criteria recommended by the Cochrane Handbook for Systematic Reviews of interventions. Such statistical analyses as heterogeneity analysis,meta-analysis,sensitivity analysis and funnel plot analysis were performed using the Review Manager 5.2.6 software. Results：Fourteen qualified trials were included. The risk of bias was generally high and clinical heterogeneity exists among them. Meta-analysis shows that the associated prescriptions of Gualou and Xiebai can improve angina pectoris（RR=1.24,95%CI[1.18,1.31]） and ECG manifestations（RR=1.29,95%CI[1.19,1.39]）,funnel plot is asymmetry. Conclusion：Current evidence indicates that treating unstable angina pectoris with the associated prescriptions of Gualou and Xiebai can improve the efficacy on unstable angina pectoris. Due to the low quality of included studies,clinical trials with adequate samples,rational design and strict execution should be carried out to provide more reliable evidence.
出处
《山东中医药大学学报》
2014年第4期316-319,共4页
Journal of Shandong University of Traditional Chinese Medicine
基金
山东省中医药科技发展计划项目(编号:2007-020)
关键词
瓜蒌薤白类方药
不稳定型心绞痛
随机对照试验
系统评价
associated prescriptions of Gualou and Xiebai
unstable angina pectoris
randomized controlledtrial
meta-analysis
