摘要
目的观察噻托溴铵联合布地奈德治疗轻中度支气管哮喘的临床疗效。方法选择我院2011年11月—2012年12月诊治的轻中度支气管哮喘患者60例,随机分为观察组和对照组,每组30例。对照组患者吸入布地奈德,观察组吸入布地奈德+噻托溴铵。检测两组患者治疗前及治疗后8周第一秒用力呼气容积(FEV1)、呼气峰流速(PEF);记录两组患者治疗后8周支气管哮喘急性发作次数及治疗期间不良反应情况。结果两组患者治疗前FEV1及PEF比较,差异均无统计学意义(P>0.05);两组患者治疗后FEV1及PEF高于治疗前,且观察组患者治疗后FEV1及PEF高于对照组(P<0.05)。治疗组患者治疗后8周支气管哮喘急性发作次数为(2.3±0.2)次,低于对照组的(9.2±0.3)次(P<0.05)。观察组患者治疗期间出现口干2例,对照组患者治疗期间出现失眠1例,两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论噻托溴铵联合布地奈德治疗轻中度支气管哮喘疗效确切,可有效改善患者肺功能,减少支气管哮喘急性发作次数。
Objective To observe the effect of Tiotropium combined with Budesonide on bronchial asthma. Methods From November 2011 to December 2012 ,60 patients with bronchial asthma were chosen in our hospital and randomly divided into groups observation and control,each of 30 cases. Control group given Budesonide inhalation,while observation group given Budesonide and Tiotropium inhalation. FEV1 and PEF were detected before treatment and 8 weeks after treatment in both groups, and frequency of acute episode of asthma and adverse reactions recorded. Results There was no significant differences of FEV1 and PEF between the two groups before treatment;after treatment,FEV1 and PEF were significantly higher than those before treatment in both groups（P﹤0. 01）,and FEV1 and PEF were significantly higher of observation group than those of control group（P﹤0. 05）. The frequency of acute episode of asthma of observation group was（2. 3 ±0. 2）times,was lower than that of control group of（9. 2 ±0. 3）times（P﹤0. 05）. Two cases in observation group occurred dryness of mouth,1 case in con-trol group occurred sleeplessness,the incidence of adverse reactions between the two groups was not significantly different（ P﹥0. 05）. Conclusion Tiotropium combined with Budesonide has a great effect in the treatment of bronchial asthma,which can effectively improve patients＇ lung function and reduce the frequency of acute episode of bronchial asthma.
出处
《实用心脑肺血管病杂志》
2014年第8期82-83,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
