期刊文献+

线粒体转位蛋白与心血管疾病 被引量:2

下载PDF
导出
摘要 线粒体转位蛋白(TSPO)是位于线粒体外膜具有5个跨膜结构域的蛋白。TSPO配体可通过维持心脏电活动、保证线粒体能量供给、阻止线粒体膜电位下降及抑制活性氧释放等途径,发挥心脏保护作用,并可作为包括心律失常、心肌缺血再灌注损伤、心肌肥厚、动脉粥样硬化与大血管性血管炎等疾病的潜在治疗靶点。
出处 《国际心血管病杂志》 2014年第4期227-229,共3页 International Journal of Cardiovascular Disease
  • 相关文献

参考文献22

  • 1Papadopoulos V, Baraldi M, Guilarte T, et al. Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function[J]. Trends Pharmacol Sci, 2006, 27(8):402-409. 被引量:1
  • 2Papadopoulos V, Liu J, Culty M. Is there a mitochondrial signaling complex facilitating cholesterol import? [J]. Mol Cell Endocrinol, 2007, 265 266:59-64. 被引量:1
  • 3Rupprecht R, Papadopoulos V, Rammes G, et al. Translocator protein (18kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders [J]. Nat Rev Drug Discov, 2010, 9(12);971 988. 被引量:1
  • 4Qi X, Xu J, Wang F, et al. Translocator protein (18 kDa) : a promising therapeutic target and diagnostic tool for cardiovascular diseases [J]. Oxid Med Cell Longev, 2012, 2012 : 162934. 被引量:1
  • 5Surinkaew S, Chattipakorn S, Chattipakorn N. Roles of mitochondrial benzodiazepine receptor in the heart[J]. Can J Cardiol, 2011, 27(2):262. e3-e13. 被引量:1
  • 6Brown DA, O' Rourke B. Cardiac mitochondria and arrhythmias EJT. CardiovascRes, 2010, 88(2):241 249. 被引量:1
  • 7Brown DA, Aon MA, Akar FG, et al. Effects of 4'- chlorodiazepam on cellular excitation contraction coupling and ischaemia reperfusion injury in rabbit heart [J]. Cardiovasc Res, 2008, 79(1):141 149. 被引量:1
  • 8Ferdinandy P, Schulz R, Baxter GF. Interaction of cardiovascular risk factors with myoeardial ischemia/reperfusion injury, preconditioning, and postconditioning [J]. Pharmacol Rev, 2007, 59(4) :418-458. 被引量:1
  • 9Di Lisa F, Bernardi P. Mitochondria and ischemia-reperfusion injury of the heart., fixing a hole[J]. Cardiovasc Res, 2006, 70(2):191 199. 被引量:1
  • 10Xiao J, Liang D, Zhang H, et al. 4' Chlorodiazepam, a translocator protein (18 kDa) antagonist, improves cardiac functional recovery during postischemia reperfusion in rats [J]. Exp Biol Med, 2010, 235(4)478 486. 被引量:1

二级参考文献22

  • 1Vizioli L, Muscari S, Muscari A. The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases[J]. Int J ClinPract, 2009,63(10):1509-1515. 被引量:1
  • 2Bath PM, Butterworth R.I. Platelet size.- measurement, physiology and vascular disease[J]. Blood Coagul Fibrinolysis, 1996, 7(2):157-161. 被引量:1
  • 3Nadar S, Blann AD, Lip GY. Platelet morphology and plasma indices of platelet activation in essential hypertension: effects of amlodipine based antihypertensive therapy[J]. Ann Med, 2004,36(7) :552-557. 被引量:1
  • 4Papanas N, Symeonidis G, Maltezos E, et al. Mean p|atelet volume in patients with type 2 diabetes mellitus [J]. Platelets, 2004,15(8) :475-478. 被引量:1
  • 5Pathansali R, Smith N, Bath P. Altered megakaryocyte platelet haemostatie axis in hypercholesterolaemia [ J]. Platelets, 2001,12(5) :292-297. 被引量:1
  • 6Coban E, Ozdogan M, Yazicioglu G, et al. The mean platelet volume in patients with obesity[J]. Int J Clin Pract, 2005, 59(8) : 981-982. 被引量:1
  • 7Demirin H, Ozhan H, Uegun T, et al. Normal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic study [J]. Thromb Res, 2011, 128 (4): 358-360. 被引量:1
  • 8Peng L, Yang J, Lu X, et al. Effects of biological variations on platelet count in healthy subjects in China[J]. Thromb Haemost, 2004,91 (2) :367-372. 被引量:1
  • 9Chu SG, Becker RC, Berger PB, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta analysis[J]. J Thromb Haemost, 2010,8 ( 1 ) : 148-156. 被引量:1
  • 10Varol E, Icli A, Ozaydin M, et al. Mean platelet volume is elevated in patients with myocardial infarction with normal coronary arteries, as in patients with myocardial infarction with obstructive coronary artery disease[J]. Scand J Clin Lab Invest, 2009,69(5) :570-574. 被引量:1

同被引文献12

引证文献2

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部