摘要
目的探讨乙肝病毒感染或携带产妇乳汁、唾液的传染性,为母婴密切接触提供科学依据。方法选取50例乙肝大三阳患者,70例乙肝小三阳患者,对其血清、乳汁、唾液分别进行HBV-DNA检测,另选30例健康产妇作为对照,对其结果进行分析。结果乙肝大三阳患者与乙肝小三阳患者的血清、乳汁、唾液HBV-DNA的阳性率之间均有显著差异(χ2=59.64,69.31,70.13;P均<0.01);乙肝大三阳患者血清与乳汁、唾液的HBV-DNA阳性率均无统计学差异(χ2=3.40,1.60;P均>0.05);乙肝小三阳患者血清与乳汁、唾液的HBV-DNA阳性率均有统计学差异(χ2=6.80,4.46;P<0.05);乙肝大三阳患者与乙肝小三阳患者两组产妇乳汁和唾液HBV-DNA阳性率之间无显著差异(χ2=0.38,0.28;P均>0.05);产妇乳汁、唾液中HBV-DNA阳性率与血清中HBV-DNA载量呈显著正相关(r=0.961,0.938;P<0.01)。结论乙肝产妇的乳汁、唾液是否具有传染性与血清中病毒载量有关;乳汁、唾液的HBV-DNA检测从一定程度上可代替血清检测,优点为取材方便,产妇无痛苦易接受,更有安全感。
Objective To discuss the infection of breast milk and saliva of parturients with HBV and provide scientific basis for prevention of close contact of mother- to- infant. Methods The 50 parturients positive for HBsAg（＋）,HBeAg（＋）, HBcAb（＋）and another 70 positive for HBsAg（＋）, HBeAb（＋）, HBcAb（＋）were selected. HBV-DNA in the serum, breast milk and saliva of subjects in both groups were detected, Thirty healthy ones were chosen as control. The results of detection were analyzed. Results The positive rates of HBV-DNA in serum, breast mill and saliva of subjects between the two groups were significantly different （X2=59.64, 69.31, 70.13, P〈0.01） . The HBV-DNA positive rate in serum was not significantly different compared to that in breast milk and saliva of parturients of HBsAg（＋）,HBeAg（＋）and HBcAb（＋） （X2 = 3.40, 1.60, respectively, P〉0.05）; The HBV-DNA positive rate in serum in those of HBsAg（＋）,HBeAb（＋） and HBcAb（＋） significantly different compared with that in breast milk and saliva （χ2= 6.80,4.46, respectively,P〈0.05）; No significant difference in the DNA positive rate in breast milk and saliva was noticed between the two groups （χ2 = 0.38, 0.28, respectively, P 〉 0.05）; The number of copies of HBV-DNA in the serum of parturients were positively correlated with the HBV DNA positive rate in breast milk and saliva of the parturients （r = 0.961, 0.938, respectively, P〈0.01）, but the HBV-DNA positive rate in saliva was slightly higher than that of breast milk. Conclusion The infectivity of HBV in breast milk and saliva of parturients with HBV is associated with the viral load in the serum, the detection of HBV-DNA in breast milk and saliva can, to some extent, replace the detection of serum as they are easy for sampling, painless and safe for detection.
出处
《中国热带医学》
CAS
2014年第7期849-851,共3页
China Tropical Medicine
关键词
HBV—DNA
乳汁
唾液
母婴传播
HBV-DNA
Breast milk
Saliva
Mother- to- infant transmission
