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重复经颅磁刺激对精神分裂症模型大鼠海马Caspase-3表达的影响 被引量:6

Influence of repetitive transcranial magnetic stimulation on the expression of Caspase-3 protein in schizophrenic rats
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摘要 目的 探讨重复经颅磁刺激(rTMS)对精神分裂症模型大鼠海马神经元Caspase-3基因表达的影响.方法 将50只SD大鼠随机分为5组:正常组、模型组、西药组、实验组、对照组.除正常组外,其他4组大鼠注射阿朴吗啡盐酸盐半水诱发大鼠精神分裂症模型;实验组接受rTMS治疗;对照组治疗方法与实验组相同,但刺激时线圈与头皮的表面的角度为90°.西药组最后7d腹腔注射氯丙嗪.采用免疫组化法比较各组大鼠海马Caspase-3的表达情况.结果 反映Caspase-3表达的平均光密度值和平均灰度值在5组大鼠间比较差异均有统计学意义(F分别为7.412,59.962;P<0.01).进一步两两比较,模型组和对照组的平均光密度值高于正常组,平均灰度低于正常组,差异有统计学意义(P<0.05).与模型组比较,实验组和西药组平均灰度值高于模型组,平均光密度也低于模型组,差异有统计学意义(P<0.05),说明治疗后大鼠海马Caspase-3的表达均明显降低.结论 rTMS能调控精神分裂症模型大鼠海马神经元Caspase-3基因的表达,抑制神经元凋亡.
出处 《神经疾病与精神卫生》 2014年第3期288-290,共3页 Journal of Neuroscience and Mental Health
关键词 重复经颅磁刺激 精神分裂症 CASPASE-3 大鼠 Repetitive transcranial magnetic stimulation Schizophrenia Caspase-3 Rats
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