摘要
目的:评价有生育需求中老年男性精子参数的变化。方法:42例50~58岁有生育需求男性的精液标本,按照其既往生育史分组,A组:继发性不育23例,平均年龄52.9±2.2(50~58)岁;B组:原发性不育19例,平均年龄52.7±2.7(50~58)岁。按世界卫生组织手册(WHO,2010)方法,检测患者的精子活动率、前向运动精子率、精子浓度、精子畸形率、畸形精子指数和精子顶体完整率。结果:A组的畸形精子率显著低于B组(P0.05)。与WHO手册(2010)的参考值对照,A、B组的精子活动率均数、前向运动精子率均数和B组的正常形态精子率均数低于参考值下限。A组和B组分别有11例(47.8%)、5例(26.3%)的精子活动率、前向运动精子率、精子浓度和正常形态精子率达到WHO的参考值范围,但达到WHO参考值的例数比率组间无统计学差异(P〉0.05)。结论:50~58岁有生育需求中老年男性的精子参数低下,但存在明显的个体差异。
Objective: To investigate sperm parameters from semen of men aged 50-58 years who wanted to be father. Methods: Forty-two men aged 50-58 years were enrolled into this study. These men visited the infertility clinic and wanted to be father. Based on their fertility history, 42 men were divided into two groups: group A, 23 cases, 52.9±2.2 (50-58) years, secondary infertility; group B, 19 cases, 52.7±2.7 (50-58) years, primary infertility. According to the WHO manual (2010), sperm parameters including sperm motility, progressive motility, sperm concentration, sperm abnormal form, teratozoospermia index, and acrosome integrity were determined. Results: Group B had higher sperm abnormal forms than that of group A (P〈0.05), and the rest sperm parameters were not found significant differences between these two groups (P〉0.05). According to the WHO reference values, sperm motility and progressive motility in groups A and B did not reach the lower reference limit, and normal morphology in group B did not reach the lower reference limit. In groups A and B, 11 and 5 cases respectively, had normal values on sperm motility, progressive motility, sperm concentration, and sperm normal morphology. Conclusion: Men aged 50-58 years would have poor sperm parameters and obvious individual difference for sperm quality.
出处
《生殖与避孕》
CAS
CSCD
2014年第7期599-602,共4页
Reproduction and Contraception
关键词
精子发生
精子
顶体
衰老
spermatogenesis
sperm
acrosome
aging