摘要
母-胎界面免疫调节功能的异常是导致复发性流产(recurrent spontaneous abortion,RSA)的一个重要病因,其作用机制尚不清楚。趋化因子及其受体参与调控母-胎界面免疫细胞的定向招募和活化,在免疫耐受状态的维持、新血管的生成、滋养层细胞的增殖和侵袭过程中发挥重要作用。因此,母-胎界面趋化因子及其受体功能的异常,可能会打破免疫耐受状态,导致胚胎植入和胎盘形成障碍,从而引起流产。
Immune dysregulation at the maternal-fetal interface has been recognized as a critical pathogeny of the recurrent spontaneous abortion （RSA）, but the mechanisms underlying such a local immune dysregulation are not fully understood. Chemokines and their receptors have been demonstrated to be involved in the specific recruitment and activation of corresponding leucocytes, and play essential roles in maintaining the status of immune tolerance, angiogenesis, as well as regulating the proliferation and invasion of trophoblasts. Thus, the dysfunctions of chemokines and their receptors at the maternal-fetal interface would cause the failures of embryo implantation and placenta formation that initiating the early pregnancy loss.
出处
《生殖与避孕》
CAS
CSCD
2014年第7期548-555,共8页
Reproduction and Contraception
关键词
母-胎界面
复发性流产(RSA)
趋化因子
趋化因子受体
免疫耐受
maternal-fetal interface
recurrent spontaneous abortion （RSA）
chemokines
chemokine receptor
immune tolerance
