期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

以淋巴管生成自分泌轴为标靶的抗肿瘤研究进展

Targeting lymphangiogenesis autocrine axis to prevent tumor progression
下载PDF
导出
摘要 淋巴管是人类癌症发生转移的重要途径,作者通过对VEGF-C(VEGF-D)/VEGFR-3信号系统的研究和综述,讨论了该信号系统是调控肿瘤淋巴管生成的重要调控因子以及阻断该信号轴。 The lymphatic vasculature is an important route for the metastatic spread of human cancer. In this review, we discuss the evidence supporting a role for VEGF- C（ VEGF -D）/VEGFR- 3 signalling system in the spread of cancer and potential approaches for blocking this system to prevent tumour metastasis.
作者 张伟 冯晨 任凤云
机构地区 牡丹江医学院 牡丹江医学院附属红旗医院
出处 《现代肿瘤医学》 CAS 2014年第7期1703-1706,共4页 Journal of Modern Oncology
基金 国家自然科学基金(编号:81241088)
关键词 淋巴管生成自分泌轴 肿瘤 综述 lymphangiogenesis autocrine axis tumor review
分类号 R730 [医药卫生—肿瘤]
  • 相关文献

参考文献34

  • 1Feng Y,Hu J,Ma J,et al.RNAi-mediated silencing of VEGF-C inhibits non-small cell lung cancer progression by simultaneously down-regulating the CXCR4,CCR7,VEGFR-2,and VEGFR-3-dependent axes-induced ERK,p38,and AKT signaling pathways[J].Eur J Cancer,2011,47(15):2353-2363. 被引量：1
  • 2Alitalo AK,Proulx ST,Karaman S,et al.VEGF-C and VEGF-D blockade inhibits inflammatory skin carcinogenesis[J].Cancer Res,2013,5:21. 被引量：1
  • 3张洁,陈墨,周彩存,徐建芳,赵印敏,粟波.血管内皮生长因子C过表达或抑制表达对人小细胞肺癌NCI-H446细胞生物学行为的影响[J].肿瘤,2012,32(2):79-84. 被引量：10
  • 4商嵩山,张剑权.VEGF-C、VEGFR-3在肿瘤淋巴管生成中作用的研究进展[J].现代肿瘤医学,2011,19(1):185-188. 被引量：15
  • 5Cao R,Bjorndahl MA,Religa P,et al.PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis[J].Cancer Cell,2004,6(4):333-345. 被引量：1
  • 6Hirakawa S,Kodama S,Kunstfeld R,et al.VEGF-A induces tumor and sentinel lymph node lymph angiogenesis and promotes lymphatic metastasis[J].J Exp Med,2005,201(7):1089-1099. 被引量：1
  • 7Joukov V,Sorsa T,Kumar V,et al.Proteolytic processing regulates receptor specificity and activity of VEGF-C[J].Embo J,1997,16(13):3898-3911. 被引量：1
  • 8Stacker SA,Stenvers K,Caesar C,et al.Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers[J].J Biol Chem,1999,274(45):32127-32136. 被引量：1
  • 9Rissanen TT,Markkanen JE,Gruchala M,et al.VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses[J].Circ Res,2003,92(10):1098-1106. 被引量：1
  • 10McColl BK,Baldwin ME,Roufail S,et al.Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D[J].J Exp Med,2003,198(6):863-868. 被引量：1

二级参考文献29

  • 1Nakashima T,kondoh S,Kitoh H,et al.Vascular endothelial growth factor-C in human gallbladder cancer and its relationship to lymph node metastasis[J].Int J Mol Med,2003,11(l):33-39. 被引量：1
  • 2Akagi K,Ikeda Y,Miyazaki M,et al.Vascular endothelial growth factor-C (VEGF-C) expression in human colorectal cancer tissues[J].Br J Cancer,2000,83(7):887-891. 被引量：1
  • 3Gunningham SP,Currie MJ,Han C,et al.The short form of the alternatively spliced flt-4 but not its ligand vascular endothelial growth factor C is related to lymph node metastasis in human breast cancers[J].Clin Cancer Res,2000,6(11):4278-4286. 被引量：1
  • 4He Y,Kozaki K,Karpanen T,et al.Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling[J].Natl Cancer Inst,2002,94(11):819-825. 被引量：1
  • 5Eikesdal HP,Dahl,Straume,et al.Tumour angiogenesis and therapy directed at the neovasculature[J].Tidsskr Nor Laegeforen,2004,124(15):1919-1922. 被引量：1
  • 6Cross MJ,Dixelius J,Matsumoto T,et al.VEGF-receptor signal transduction[J].Trends Biochem Sci,2003,28 (9):488-494. 被引量：1
  • 7Pytowski B,Goldman J,Persaud K,et al.Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody[J].Nail Cnacer Inst,2005,97(1):l4-21. 被引量：1
  • 8CAO Y.Opinion:emerging mechanisms of tumour lymphangigeneis and lymphatic metastasis[J].Nat Rev Cancer,2005,5(9):735-743. 被引量：1
  • 9Tammela T,Petrova TV,Alitalo K.Molecular lymphangiogenesis:new players[J].Trends Cell Biol,2005,15(8):434-441. 被引量：1
  • 10Su JL,Yang PC,Shih JY,et al.The VEGF-CPFIt-4 axis promotes invasion and metastasis of cancer cells[J].Cancer Cell,2006,9(3):209-223. 被引量：1

共引文献23

现代肿瘤医学
2014年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部