摘要
小儿青春发育启动与下丘脑-垂体-性腺轴的发动有关,而下丘脑促性腺激素释放激素（ gonadotropin-releasing hormone,GnRH）神经元的激活是青春期启动的关键。青春期启动过程是一个复杂的过程,GnRH又受到许多相关神经肽调节的影响。近来研究发现促性腺激素抑制激素（ gonadotropin-inhibitory hormone,GnIH）和 Kisspeptin 分别能够抑制和促进哺乳类动物的下丘脑 GnRH 的分泌,提示 GnIH 和Kisspeptin对生殖内分泌轴起着非常重要的调节作用。因此,GnIH/GPR147和Kisspeptin/GPR54两条通路可能与小儿青春发育启动密切相关。
The initiation of puberty is associated with the hypothalamus-pituitary-gonadal（ HPG） axis. The activation of gonadotropin-releasing hormone（ GnRH） is the key factor in the initiation of puberty. The initiation of puberty is a complicated process,GnRH is under the influence of many associated neuropeptides. Recently,the studies have found that GnIH and Kisspeptin can respectively inhibit and promote the hypothalamus GnRH secretion of mammals,indicating that GnIH and Kisspeptin on regulation of reproductive endocrine axis play very important roles. Therefore,GnIH/GPR147 and Kisspeptin/GPR54 pathways may be closely associated with the initiation of puberty.
出处
《国际儿科学杂志》
2014年第4期394-398,共5页
International Journal of Pediatrics
基金
国家自然科学基金资助项目（81273804）
