摘要
目的回顾性分析鼻咽癌各种临床因素与Ⅰb区淋巴结肿大的相关性,为确定鼻咽癌Ⅰb区预防照射指征提供参考。方法选取近3年来在南方医院诊断为鼻咽癌的初治患者影像资料435例,研究其T分期、N分期、Ⅱ区肿大淋巴结直径、下颌下腺侵犯、鼻腔侵犯、口咽侵犯、≥4个淋巴结引流区转移等临床高危因素与ⅠB区淋巴结肿大的相关关系。结果单因素分析显示N分期(P=0.023)、下颌下腺侵犯(P=0.045)、Ⅱ区淋巴结直径与Ⅰb区淋巴结肿大呈正相关关系。Logistic多因素分析结果显示,仅Ⅱ区淋巴结直径具有统计学意义(P=0.013)。结论鼻咽癌Ⅰb区淋巴结肿大与同侧Ⅱ区淋巴结大小呈显著正相关关系。
Objective To analyze the risk factors for level Ⅰb lymph node enlargement on CT in patients with nasopharyngeal carcinoma （NPC） and provide clinical evidence for defining the indications of prophylactic level Ⅰb irradiation. Methods A total of 435 newly diagnosed NPC patients receiving radiotherapy in Nanfang Hospital in the past 2 years were enrolled in this analysis. The correlations were analyzed with Logistic regression between level Ⅰb lymphadenopathy and the clinical risk factors including T stage, N stage, diameter of level Ⅱlymph nodes, submandibular gland involvement, nasal cavity involvement, oropharyngeal involvement, and involvement of 4 or more lymphatic drainage regions. Results Univariate analysis showed that level Ⅰb lymphadenopathy were positively correlated with N stage （P=0.023）, submandibular gland involvement （P=0.045）, and level Ⅱ lymph node diameter （P＆lt;0.001）. Multivariate Logistic regression analysis suggested a significant correlation only between the diameter of the level Ⅱ lymph nodes and level Ⅰb lymphadenopathy （P=0.013）. Conclusion Level Ⅰb lymphadenopathy is positively correlated with the size of ipsilateral level Ⅱ lymph nodes in NPC patients.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2014年第7期983-987,共5页
Journal of Southern Medical University
基金
国家自然科学基金(81071827)~~
关键词
鼻咽肿瘤
淋巴结转移
放射治疗
口腔干燥症
nasopharyngeal neoplasms
lymph node metastasis
radiotherapy
xerostomia
