摘要
目的探讨克罗恩病(CD)患者肠道菌群结构的变化及与血沉(BS)、C反应蛋白(CRP)和TNF-α的关系。方法将150例我科收治的腹痛低热患者分为CD组(n=56)和非CD组(n=94),另选取30例健康者组成对照组,检查3组样本肠道菌群结构的变化及BS、CRP和TNF-α水平并分析其与肠道菌群结构的变化的关系。结果与对照组比较,非CD患者肠杆菌、酵母菌、拟杆菌等细菌的数量均增加而真杆菌的数量则显著下降,CD病组肠杆菌、酵母菌、拟杆菌等细菌的数量均增加而真杆菌和小梭菌的数量则显著下降,CD组和非CD组患者BS、CRP和TNF-α水平均增加,与非CD组比较,CD组BS、CRP和TNF-α水平均增加,随着患者BS、CRP和TNF-α水平的提高,CD组的肠球菌数量与非CD组的酵母菌数量均增加(P<0.05)。结论 CD患者肠道菌群结构的变化与BS、CRP和TNF-α水平及真菌减少相关。
Objective To explore the relationship between the changes of the structure of intestinal flora and blood sedimentation（BS）,c-reactive protein（CRP）and TNF-αin the patients with Crohn disease（CD）. Methods A total of 150 patients with abdominal pain and low thermal were divided into a CD group（n=56）and a non-CD group（n=94）,and the control group was formed by 30 healthy persons.The intestinal flora structure changes,BS,CRP and TNF-αlevels of the 3groups were tested and the relationships between the structure change of intestinal flora and BS,CRP and TNF-αwere analyzed respectively. Results Compared with the control group,the number of enterobacteria,microzyme,bacteroid and other bacteria in the non-CD group and CP group were increased while the number of eubacterium was decreased,and the number of clostridium in the CD group was also significantly reduced（all P〈0.05）.The BS,CRP and TNF-αlevels in the non-CD group and CD group were increased,and the BS,CRP and TNF-αlevels in the CD group were higher than those of the nonCD group（all P〈0.05）.With the increases of BS,CRP and TNF-αlevels,the number of enterobacteria in the CD group and the number of microzyme in the non-CD group were increased（P〈0.05）. Conclusions The structure change of intestinal flora in patients with CD are correlated with the BS,CRP and TNF-αlevels and fungi reducing.
出处
《中国校医》
2014年第7期530-532,共3页
Chinese Journal of School Doctor
关键词
CROHN病
肠黏膜
微生物学
血沉
C反应蛋白
肿瘤坏死因子-Α
Crohn Disease
Intestinal Mucosa/microbiology
Blood Sedimentation
C-Reactive Protein
Tumor Necrosis Factor-alpha
