摘要
目的：探讨地佐辛用于无痛人工流产手术的对术后宫缩痛的影响。方法选择门诊ASAⅠ-Ⅱ级需行人工流产早孕妇女90例，随机分为3组，地佐辛组、芬太尼组及丙泊酚组，每组30例。地佐辛组于术前30 min肌肉注射地佐辛5 mg，入室后1 min内静脉注射丙泊酚1.5-2.5 mg/kg；芬太尼组1 min内静脉滴注芬太尼1.0μug/kg，3 min后于1 min内静脉注射丙泊酚1.5-2.5 mg/kg；丙泊酚组按芬太尼组方法给予丙泊酚。记录BP、HR、ECG、SpO2等生命体征，诱导时间、唤醒时间、定向力恢复时间，VAS、BCS评分以及不良反应的发生情况。结果地佐辛组SBP、DBP、HR下降低于其他2组（P＜0.05）；诱导时间、定向力恢复时间短于其他2组，丙泊酚用药量少于其他2组（P＜0.05）；VAS评分低于其他2组，血压下降、呼吸抑制等不良反应发生率低其他2组（P＜0.01）。结论地佐辛有效缓解术后宫缩痛、减少丙泊酚用量，不良反应少，安全有效，优于芬太尼联合丙泊酚，提高患者满意度。
Objective To investigate the efficacy and safety of Dezocine analgesia in painless abortion. Methods Ninety cases of outpatient with ASAⅠ-Ⅱgrade pregnancy and needed abortion were selected. All cases were divided into three groups according to random number table, and 30 cases in each group. Dezocine group （group D） were given intramuscular dezocine （5 mg） injection 30 minutes before operation and followed by propofol after being sent to operation room. Conventional fentanyl analgesic group （group F） were given intravenous fentanyl drip （1.0 μg/kg） within a minute, and followed by propofol 1.5-2.5 mg/kg intravenously within a minute 3 minutes later. Group P were given propofol in the same way as group F. Then data were recorded including vital signs （BP, HR, ECG, SpO 2, et al）, induction time, wake-up time, orientation recovery time, VAS, BCS scores, and adverse reactions. Results The falls of SBP, DBP, HR were lower in group D than that in group F and P （P〈 0.05）. The induction time, orientation recovery time were shorter than those in group F and group P. The dosage of propofol was less than that in Group F and P （P〈 0.05）. VAS score was lower than that of group P and F; and the the adverse reactions, such as hypotension, respiratory depression, were lower than those in group F and P （P〈 0.01）. Conclusion Dezocine can reduce postoperative contractive pains and propofol dosage, adverse reactions. It＆#39;s safety profile and efficacy is better than fentanyl and propofol.
出处
《北京医学》
CAS
2014年第7期569-571,共3页
Beijing Medical Journal
