摘要
FEN1是一种结构特异性的多功能核酸酶,具有5'->3'flap核酸内切酶(FEN)、缺口核酸内切酶(GEN)和核酸外切酶(EXO)三大酶切活力.在细胞内,FEN1在多条DNA代谢途径中起着重要作用,包括冈崎片段成熟、长片段碱基切除修复和端粒维持等.鉴于FEN1的复杂功能,细胞内必定存在着一套精确调控机制,以确保FEN1在合适的时间与地点发挥作用.FEN1功能失调将导致基因组的稳定性和完整性下降,最终诱发包括肿瘤在内的多种染色体相关的疾病.本文主要针对FEN1的功能调控、功能失调与肿瘤的关系做一个综述.
Flap endonuclease-1 （ FEN1 ） is a kind of structure-specific multifunctional nuclease which contains 5′〉3′flap endonuclease（ FEN） activity,gap endonuclease（ GEN） activity and exonuclease（ EXO） activity. The multiple nuclease activities of FEN1 allow it to participate in numerous DNA metabolic pathways,including Okazaki fragment maturation, long-patch base excision repair and telomere maintenance. As such,FEN1 must be precisely regulated to execute each of its functions with the right timing and in a specific subcellular location. FEN1 dysfunction will lead to genomic stability and integrity descend, and eventually induce a variety of chromosomal diseases including tumor. This review mainly targets FEN1’s functional regulation and its link to cancer.
出处
《南京师大学报（自然科学版）》
CAS
CSCD
北大核心
2014年第2期7-14,共8页
Journal of Nanjing Normal University(Natural Science Edition)
基金
国家重点基础研究发展计划(973计划)项目(2013CB911600)
国家自然科学基金(31271449)
江苏省杰出青年基金(BK20130044)
江苏省科技厅面上项目(BK2011783)
江苏省科技厅重点项目(BK20130061)
