摘要
钩藤是中医传统常用要药,近年来研究发现其有显著的神经保护作用。钩藤中的有效成分可通过互作,多途径、多靶点发挥神经保护作用。在神经保护中,钩藤可通过抗氧化清除自由基,调节神经递质及其相关受体、调节炎症因子及相关通路、抗神经细胞凋亡、降低胞内Ca2+超载、改善神经退行性病变等途径发挥功效。该文就近年来钩藤的神经保护作用相关机制的研究作一简要综述。
The Uncariae Ramulus Cum Uncis is a commonly used traditional Chinese medicine. In recent years,many studies have revealed its prominent neuroprotection function. The active ingredients in Uncariae Ramulus Cum Uncis could protect the nervous system in a multi-path and multi-target manner. Uncariae Ramulus Cum Uncis shows the neuroprotective effect by resisting oxidation,scavenging free radicals,modulating neurotransmitters and their related receptors,regulating the inflammatory factors and their related pathways,attenuating neuron apoptosis,reducing intracellular Ca2 ＋overloads and mitigating neurodegeneration. In this paper,the authors summarized the advance in studies on neuroprotective mechanisms of Uncariae Ramulus Cum Uncis.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2014年第14期2603-2607,共5页
China Journal of Chinese Materia Medica
关键词
钩藤
活性成分
抗氧化
神经保护
Uncariae Ramulus Cum Uncis
active ingredient
antioxidant
neuroprotection
