摘要
目的 观察贝前列腺素钠联合阿司匹林治疗糖尿病足的疗效及不良反应.方法 选取糖尿病足患者90例,按照随机数字表法分为观察组45例和对照组45例,两组患者均采用基础治疗,对照组在基础治疗的基础上加用阿司匹林,观察组在基础治疗的基础上采用贝前列腺素钠联合阿司匹林治疗,比较两组临床疗效和不良反应的发生情况.结果 观察组总有效率为93.3％（42/45）,明显高于对照组的84.4％（38/45）,两组差异有统计学意义（χ2=8.030,P＜0.05）;观察组创面愈合率为（81.4±2.7）％、踝背指数为（11.2±2.1）、平均愈合时间为（39.1±2.1）d、经皮氧分压为（26.3±1.8） mmHg,均明显优于对照组的（69.3±1.9）％、（8.4±2.9）、（52.3±8.2）d和（16.3±2.6） mmHg,差异均有统计学意义（t=12.72、7.92、12.06、9.97,均P＜0.05）;两组不良反应发生率差异无统计学意义（P＞0.05）.结论 贝前列腺素钠联合阿司匹林治疗糖尿病足具有较好的临床疗效,可以提高患者的溃疡愈合率,改善患者的踝背指数和经皮氧分压,明显缩短平均愈合时间,且不良反应少.
Objective To study and analyze the efficacy and adverse reactions of beraprost sodium combined with aspirin in the treatment of diabetic foot.Methods 90 cases with diabetic foot were selected and they were randomly divided into the observation group and control group,35 cases in each group.Two groups were both treated with basic treatment.On the basis of the basic treatment,the control group was given aspirin,while the observation group was treated with beraprost sodium combined with aspirin.The clinical efficacy,ulcer healing rate,ankle back index,transcutaneous oxygen pressure,average healing time and the occurrence of adverse reactions were compared between the two groups.Results The clinical effective rate of the observation group was 93.3% （42/45）,which was significantly higher than 84.4% （38/45） of the control group,the difference between the two groups was statistically significant （χ2 =8.030,P 〈 0.05）.The wound healing rate,ankle dorsal index,average healing time,the degree of improvement of transcutaneous and oxygen pressuer of the observation group were （81.4 ± 2.7） %,（11.2 ± 2.1）,（39.1 ± 2.1） d and （26.3 ± 1.8） mmHg,which were significantly better than （69.3 ± 1.9） %,（8.4 ± 2.9） %,（52.3 ± 8.2） d and （16.3 ± 2.6）mmHg of the control group.The differences of these indicators between the two groups were statistically significant（t =12.72,7.92,12.06,9.97,P 〈 0.05）.The difference of adverse reactions between the two groups was not statistically significant （P 〉 0.05）.Conclusion Beraprost sodium combined with aspirin has better clinical efficacy in the treatment of diabetic foot.It can improve the patients＇ulcer healing rate,the ankle back index,transcutaneous oxygen pressure,shorter the average healing time,and it has few adverse reactions.
出处
《中国基层医药》
CAS
2014年第13期1991-1992,共2页
Chinese Journal of Primary Medicine and Pharmacy
