摘要
为了探讨全球H5N1亚型流感病毒(IV)NA和NS基因的分子流行病学特点,本文从NCBI下载1996-2013年全球H5N1 IV的NA、NS基因序列并进行进化分析。结果显示NA和NS双基因部分缺失株在H5N1亚型IV中占有绝对的优势,NA和NS基因部分缺失能显著影响毒株间的遗传距离,2010年后分离的H5N1亚型IV的NA基因优势流行基因型是Group-6 like,NS基因优势流行基因型为Group-2 like。
To elucidate the molecular epidemiological characteristics of NA and NS genes of H5N1 subtype infl uenza viruses in the world,the sequences of NA and NS genes of H5N1 subtype infl uenza viruses from 1996 to 2013 were downloaded from NCBI database,and the phylogenetic tree was constructed. The results showed that H5N1 viruses with partial deletions in both NA and NS protein became the prevailing strains worldwide. The deletions in NA and NS proteins affected the genetic distance. In particular,H5N1 viruses isolated since 2010 possessed Group-6 like NA gene and Group-2 like NS gene.
出处
《中国动物检疫》
CAS
2014年第7期25-29,共5页
China Animal Health Inspection
基金
973计划(2011CB505003)
国家科技重大专项(2012ZX10004214-001-002)
江苏省自然科学研究重大项目(10KJA230055)
江苏省研究生科研创新计划(CXLX11_1031)
江苏省青蓝工程项目(苏教师[201027号])
教育部创新团队项目(IRT0978)
江苏省高校优势学科建设工程资助项目
