摘要
目的 :探讨室管膜下巨细胞星形细胞瘤 (SEGA)的临床病理、免疫组化特点及预后。方法 :分析 9例SEGA的临床特点 ,观察组织病理切片和免疫组化标记 ,并进行随访。结果 :SEGA出现临床症状时多为青少年 (10～ 2 0岁 ) ;好发于侧脑室 ,由大的节细胞样星形细胞组成 ;免疫组化显示肿瘤细胞表达GFAP ,NSE和Vim ,不表达EMA ;随访 2～ 2 3月 ,8例存活。结论 :SEGA为生长缓慢良性肿瘤 ,属WHOⅠ级 ,常伴随结节性硬化 ;需与室管膜瘤。
Purpose To study the clinicopathology, immunohistochemical characteristic and prognosis of subependymal giant cell astrocytoma(SEGA). Methods Nine cases of SEGA were studied by clinicopathology and immunohistochemistry, all cases were followed up. Results SEGA typically occurred during the first two decades of life, arising in the wall of the lateral ventricles and composed of large ganglioid astrocytes. Immunohistochemistry showed GFAP, NSE and vimentin positive and EMA negative; 8 cases were lived during 2～23 months. Conclusion SEGA is a benign, slowly growing tumor corresponding to WHO grade I, it is the most common central nervous system neoplasm in tuberous sclerosis complex, should be differentiated with ependymoma, gemistocytic diffuse astrocytoma and giant cell glioblastoma .
出处
《临床与实验病理学杂志》
CAS
CSCD
2002年第3期291-294,共4页
Chinese Journal of Clinical and Experimental Pathology
